中国临床药理学杂志2024，Vol.40Issue(19)：2901-2904,4.DOI:10.13699/j.cnki.1001-6821.2024.19.028
甲氨蝶呤治疗儿童急性淋巴细胞白血病的临床应用分析
Clinical application analysis of methotrexate in the treatment of children with acute lymphoblastic leukemia
摘要
Abstract
Objective To analyze the literature on methotrexate(MTX)in the treatment of children with acute lymphoblastic leukemia(ALL)from the perspective of bibliometric analysis,and to understand the research status and future research trend.Methods Literature related to MTX treatment of children with ALL was retrieved from CNKI,and CiteSpace 6.1.R6 Advanced software was applied to the literature for trend of number of publications,keyword co-occurrence,keyword clustering and keyword emergence.Results A total of 205 literatures were included,and the number of published papers fluctuated.The main research hotspots of using MTX to treat children with ALL were"high-dose administration"and"adverse drug reactions",and future research trends will focus on"gene detection"and"therapeutic drug monitoring(TDM)".Conclusion MTX played an important role in the treatment of children with ALL,and research on MTX treatment for children with ALL focused on high-dose administration and adverse drug reactions of MTX in recent years.关键词
甲氨蝶呤/儿童急性淋巴细胞白血病/CiteSpace/可视化分析/文献计量分析Key words
methotrexate/children with acute lymphoblastic leukemia/CiteSpace/visualization analysis/bibliometric analysis分类
医药卫生引用本文复制引用
蔡文君,王梓凝,陈超阳,周颖..甲氨蝶呤治疗儿童急性淋巴细胞白血病的临床应用分析[J].中国临床药理学杂志,2024,40(19):2901-2904,4.基金项目
国家科技重大专项-重大新药创制基金资助项目(2017ZX09304029-006-001) （2017ZX09304029-006-001）
