中国临床药学杂志2024，Vol.33Issue(8)：561-566,6.DOI:10.19577/j.1007-4406.2024.08.001
开腹肝切除围术期路径化多模式镇痛用药管理及其实施效果评价
Effectiveness of perioperative path-based multimodal analgesic regimens for open hepatectomy
摘要
Abstract
AIM To study the effectiveness of a perioperative multimodal analgesia management and medication regimen for patients undergoing open hepatectomy.METHODS A total of 216 patients who underwent open hepatectomy in the hepatobiliary surgery department were recruited in the hospital from April 2020 to May 2021.Of these,139 patients who did not follow the regimen were included in the observation group(from April 2020 to October 2020),while 77 patients were included in the study group(from November 2020 to May 2021),following the multimodal analgesia medication regimen.Postoperative analgesic outcomes and adverse events were compared between 2 groups.RESULTS The control rate of moderate to severe postoperative pain in the study group was significantly higher than that in the observation group(83.1％vs 69.8％,P＜0.05).There was no significant difference between the groups in pain scores at 6 h(2.0 vs 2.0,P＞0.05)and 24 h(1.0 vs 1.0,P＞0.05)post-surgery,as well as the incidence of postoperative nausea and vomiting(40.3％vs 43.9％,P＞0.05).However,pain scores at 48 h(0.0 vs 1.0,P＜0.01)and 72 h(0.0 vs 0.0,P＜0.01)post-surgery were significantly lower in the study group,and the hospitalization duration was shorter(15 vs 19 days,P＜0.01),with a lower incidence of gastrointestinal dysfunction(26.0％vs 41.0％,P＜0.05).CONCLUSION The perioperative multimodal analgesia management and medication regimen for open hepatectomy can optimize postoperative pain control and improve patient outcomes.关键词
开腹肝切除/临床药师/多模式镇痛用药方案/临床结局Key words
open hepatectomy/clinical pharmacist/multimodal analgesic regimen/clinical outcome引用本文复制引用
陈大宇,过佳月,杜瑶,张海霞,陆瑶,朱新华,谢菡..开腹肝切除围术期路径化多模式镇痛用药管理及其实施效果评价[J].中国临床药学杂志,2024,33(8):561-566,6.基金项目
南京临床医学中心建设项目(编号:宁卫科教[2020]1号) （编号:宁卫科教[2020]1号）
南京大学中国医院改革发展研究院课题项目及南京鼓楼医院医学发展医疗救助基金会资助项目(编号:NDYG2021044) （编号:NDYG2021044）
