摘要
Abstract
Objective To explore the efficacy of tacrolimus combined with narrow-band UVB in the treatment of atopic dermatitis.Methods A total of 120 patients with atopic dermatitis who were treated at the author's hospital from February 2021 to December 2022 were selected and randomly divided into three groups using a simple randomization method:group A(tacrolimus,40 cases),group B(moisturizer combined with narrow-band UVB,40 cases),and group C(tacrolimus combined with narrow-band UVB,40 cases).All three groups were treated continuously for 2 months.Clinical signs[Scoring Atopic Dermatitis Index(SCORAD),Chinese version of Atopic Dermatitis Control Tool(ADCT)],pruritus[Peak Pruritus-Numerical Rating Scale(PP-NRS)],cytokines[serum apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),interleukin-4(IL-4),interleukin-10(IL-10)],aesthetic effects[overall area of dermatitis,scores of objective signs(erythema,exfoliation,lichenoid change)],and quality of life[Dermatological Life Quality Index(DLQI)]were compared among the three groups before treatment,and after 1 month and 2 months of treatment.The adverse reactions in the three groups were recorded during treatment,and recurrence was assessed during a 3-month follow-up period after treatment.Results After 1 and 2 months of treatment,SCORAD,ADCT,PP-NRS,ApoB,IL-4,IL-10,overall dermatitis area,objective sign scores,and DLQI scores in all three groups were significantly reduced compared to before treatment,with group C showing significantly lower levels in these indicators compared to group A and group B(all P＜0.05).ApoA1 levels were significantly increased in all three groups compared to before treatment,with group C showing significantly higher levels than groups A and B(all P＜0.05).There were no significant differences in the incidence rates of adverse reactions among the three groups during treatment(P＞0.05).The recurrence rate in group C during the 3-month follow-up period was significantly lower than that in group A and group B(P＜0.05).Conclusion Tacrolimus combined with narrow-band UVB has a significant therapeutic effect on patients with atopic dermatitis,effectively relieving symptoms and pruritus,improving quality of life,and enhancing aesthetic outcomes.关键词
特应性皮炎/他克莫司/窄谱UVB/美学效果Key words
atopic dermatitis/tacrolimus/narrow-band UVB/aesthetic effect分类
医药卫生
