中国美容医学2024，Vol.33Issue(10)：45-49,5.
光动力联合疗法治疗玫瑰痤疮临床效果分析
Analysis of the Clinical Effect of Photodynamic Combination Therapy in the Treatment of Rosacea
摘要
Abstract
Objective To observe the clinical effect of photodynamic combination therapy on rosacea.Methods A total of 200 patients with rosacea treated at the author's hospital from January 2022 to January 2023 were selected for the study.They were randomly divided into two groups,the study group and the control group,with 100 patients in each group.Both groups were further subdivided into erythema telangiectatic type and papulopustular type.The control group was treated with topical clindamycin metronidazole liniment and a medical skin healing biofilm.The study group received 5-aminolevulinic acid photodynamic therapy in addition to the treatment given to the control group.Clinical symptom scores,stratum corneum hydration,transepidermal water loss(TEWL),and serum levels of interleukin-17(IL-17)and interferon-gamma(IFN-γ)were compared between the two groups before treatment and 4 weeks after treatment.The treatment efficacy,Demodex negative conversion rate,and incidence of adverse reactions were recorded in both groups.Results The total effective rate and Demodex negative conversion rate in both subtypes of the study group were higher than those in the control group(P＜0.05).After 4 weeks of treatment,clinical symptom scores in both subtypes of the study group were lower than those in the control group(P＜0.05).The stratum corneum hydration in both subtypes of the study group was higher,and TEWL was lower,compared to the control group(P＜0.05).Serum levels of IL-17 and IFN-γ in both subtypes of the study group were lower than those in the control group after 4 weeks of treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Photodynamic combination therapy for erythema telangiectatic and papulopustular rosacea effectively reduces clinical symptoms,decreases inflammatory factor expression,improves skin barrier function,and successfully eliminates Demodex,with significant therapeutic benefits.关键词
玫瑰痤疮/5-氨基酮戊酸光动力/克林霉素甲硝唑搽剂/皮肤屏障功能/干扰素-γ/白介素-17/联合疗法Key words
rosacea/5-aminolevulinic acid photodynamic therapy/clindamycin metronidazole liniment/skin barrier function/interferon-γ/interleukin-17/combination theropy分类
医药卫生引用本文复制引用
宋红娟,马国安,闫婷,刘丽丽,丁红炜..光动力联合疗法治疗玫瑰痤疮临床效果分析[J].中国美容医学,2024,33(10):45-49,5.基金项目
衡水市科技计划项目(编号:2021014078Z) （编号:2021014078Z）
