中国实用妇科与产科杂志2024，Vol.40Issue(9)：953-956,4.DOI:10.19538/j.fk2024090121
蒂诺安与唯散宁治疗卵巢子宫内膜异位囊肿疗效比较分析
Comparative analysis of the therapeutic effects of Dinuoan and Visanne in the treatment of ovarian endometri-otic cysts
摘要
Abstract
Objective Comparative analysis of the clinical efficacy and side effects of Dinuoan and Visanne in the treat-ment of ovarian endometriotic cysts.Methods A total of 157 patients diagnosed with ovarian endometriotic cysts by ul-trasound were recruited at Women's Hospital school of medicine Zhejiang University from April 2022 to June 2023.Among them,49 patients were treated with Dinuoan(study group),and 108 patients were treated with Visanne(control group).The size of ovarian endometriotic cysts(cyst maximum diameter and volume),pain VAS scores,and abnormal uterine bleeding were observed before and after treatment in both groups.The non-inferiority tests were used to analyze the differences in efficacy and side effects between two groups.Results After 6 months of treatment,Dinuoan was as ef-fective as Visanne in reducing the maximum diameter of endometrioma.The effect of Dinuoan about reducing VAS score was also not inferior to Visanne.However,the therapeutic effect in reducing the volume of ovarian cysts was uncertain.Af-ter 3 or 6 months of treatment,the maximum diameter,volume of cyst and the VAS score of both groups significantly de-creased compared to the initial value(P=0.001).Furthermore,the difference in cyst volume reduction after 3 months treatment did not reach statistical significance between the two groups(P=0.306).The difference in cyst volume reduction after further 3 months treatment did not reach statistical significance between the two groups(P=0.479).There was no sig-nificant difference in the incidence of abnormal uterine bleeding after 6 months of treatment between the two groups(P=0.146).In addition,there was no change in uterine volume and uterine fibroid size after 6 months treatment for both groups of patients(P＞0.05).Conclusions Dinuoan demonstrates equivalent efficacy to Visanne in reducing the endo-metriotic cyst maximum diameter,relieving the dys-menorrhea and has similar side effects.But the effect on cyst volume is uncertain.关键词
地诺孕素/子宫内膜异位症/痛经/卵巢子宫内膜异位囊肿/异常子宫出血Key words
dineogest/endometriosis/dysmenorrhea/endometriotic cyst/abnormal uterine bleeding分类
医药卫生引用本文复制引用
何佳怡,朱丽波,张信美..蒂诺安与唯散宁治疗卵巢子宫内膜异位囊肿疗效比较分析[J].中国实用妇科与产科杂志,2024,40(9):953-956,4.基金项目
国家重点研发计划(2022YFC2704003) （2022YFC2704003）
