中国实用内科杂志2024，Vol.44Issue(9)：760-764,5.DOI:10.19538/j.nk2024090107
基于体素形态学多维度分析系统性红斑狼疮患者脑实质体积变化的研究
Multidimensional voxel-based morphometric analysis of brain parenchymal volume variations in patients with systemic lupus erythematosus
摘要
Abstract
Objective To investigate alterations in brain parenchymal volume in patients with systemic lupus erythematosus(SLE)using the voxel-based morphometry(VBM)approach.Methods SLE patients with normal routine brain magnetic resonance imaging(MRI)and healthy controls(HCs)in Department of Rheumatology and Immunology,First Affiliated Hospital of Kunming Medical University from 2007 to 2021 were recruited at a 1∶1 matching ratio based on gender and age.The 3D-T1 brain structural magnetic resonance images were segmented and the total brain volume,average brain region volume and voxel brain map were calculated,which were compared from multiple dimensions.Results At the whole brain level,the gray matter volumes of SLE group were significantly reduced compared with those of the HCs group(P＜0.05).At the level of brain regions,the volume of 15 brain regions such as the bilateral fusiform gyrus and insula decreased significantly(after FDR correction,q＜0.05).At the cluster level,the volume of the right rectus in the gray matter area decreased(GRF correction,Voxel P＜0.001,Cluster P＜0.01).Conclusion SLE patients exhibit brain volume reduction at multiple dimensions.VBM methods can detect brain parenchymal atrophy in SLE patients with normal MRI.关键词
基于体素的形态学分析/系统性红斑狼疮/脑实质体积/结构磁共振成像Key words
voxel-based morphometric analysis/systemic lupus erythematosus/brain parenchymal volume/structural magnetic resonance imaging分类
医药卫生引用本文复制引用
沈枫,杨一帆,白茹,李姝,刘爽,程宇琪,徐健..基于体素形态学多维度分析系统性红斑狼疮患者脑实质体积变化的研究[J].中国实用内科杂志,2024,44(9):760-764,5.基金项目
国家自然科学基金(32270947,81760296) （32270947,81760296）
云南省高层次卫生技术人才(领军人才)培养项目(L-2019004) （领军人才）
云南省"万人计划"名医人才专项(YNWR-MY-2018-040) （YNWR-MY-2018-040）
云南省皮肤免疫性疾病临床医学中心(ZX2019-03-02) （ZX2019-03-02）
风湿免疫性疾病多中心临床科研转化平台(2018ZF016) （2018ZF016）
