中医肿瘤学杂志2024，Vol.6Issue(5)：18-24,7.DOI:10.19811/j.cnki.ISSN2096-6628.2024.09.003
从"虚、郁、滞、瘀"论肠炎-癌转化中医核心病机的生物学内涵
Discussion on the Biological Connotation of Core Pathogenesis in Traditional Chinese Medicine Regrading Enteritis-Cancer Transformation from"Deficiency,Depression,Stagnation,and Stasis"
摘要
Abstract
The process of intestinal transformation from normal mucosa to cancer is relatively long,starting from inflammatory state,progressing to precancerous lesions and precancerous state,and finally to colon cancer,abbreviated as enteritis-cancer transformation disease.In the process of enteritis-cancer transformation,the core pathogenesis of"deficiency,depression,stagnation,and stasis"is closely related to the nervous and immune status of body,as well as the inflammatory response induced by imbalance.Weakness of the spleen and stomach leads to inflammation,depression promotes inflammation,brain and intestine damage mutually,qi and blood circulation runs not fluently,phlegm generates in the intestine,resulting in qi stagnation,phlegm coagulation,and blood stasis.At the beginning,accumulation cannot be formed,and stagnation cannot be eliminated,resulting in accumulation.From the perspective of modern biology,the release of pro-inflammatory and anti-inflammatory factors mediated by T helper cell(Th)17/regulatory T cell(Treg)affects the dynamic balance of gut microbiota structure within the intestinal microenvironment,which is transmitted to the cerebral center through neuroimmune mechanisms,and brain interacts with gut.Under the stimulation of internal and external factors,the imbalance of one environment can cause local and overall imbalance,leading to the gradual development of inflammation to an uncontrollable state and driving gene mutations to form cancer.Focusing on the core pathogenesis of"deficiency,depression,stagnation,and blood stasis",starting from strengthening the spleen and stomach,relieving inflammation,promoting stagnation and blood stasis,treating inflammation before cancer,and blocking the transformation from inflammation to cancer can provide ideas and references for the clinical prevention and treatment of enteritis-cancer transformation diseases.关键词
积聚/炎-癌转化/脾胃虚弱/郁滞/血瘀/神经免疫Key words
accumulation/inflammation-cancer transformation/weakness of the spleen and stomach/stagnation/blood stasis/neuroimmunity分类
医药卫生引用本文复制引用
郑国银,张旖晴,王欣,彭浩,杨洋,苏晓兰,魏玮..从"虚、郁、滞、瘀"论肠炎-癌转化中医核心病机的生物学内涵[J].中医肿瘤学杂志,2024,6(5):18-24,7.基金项目
国家自然科学基金面上项目(编号:81573653) （编号:81573653）
国家中医药管理局第七批全国名老中医药专家学术经验传承项目(编号:2021-272) （编号:2021-272）
国家重点研发计划"中医药现代化研究"专项(编号:2022YFC3500503) （编号:2022YFC3500503）
上海市科技创新行动计划项目(编号:20S21900400) （编号:20S21900400）
上海市卫健委中医药平台支撑科研专项(编号:2024PT006). （编号:2024PT006）
