大学化学2024，Vol.39Issue(8)：241-246,6.DOI:10.3866/PKU.DXHX202401029
综合有机化学实验:三唑并嘧啶类化合物的合成与表征
Comprehensive Organic Chemistry Experiment:Synthesis and Characterization of Triazolopyrimidine Compounds
摘要
Abstract
Triazolopyrimidine compounds containing carboxyl and thioether groups were synthesized using 3-amino-5-mercapto-1,2,4-triazole,benzyl bromide,and diethyl ethoxymethylenemalonate (EMME) as starting materials.The synthesis involved nucleophilic substitution,cyclization,and hydrolysis reactions.The resulting products were characterized and analyzed for their structures.The experiment included techniques such as heating reflux,TLC (thin-layer chromatography) detection,filtration,and recrystallization,which aimed to enhance students'skills in multi-step organic compound synthesis and spectral analysis.Triazolopyrimidine compounds are widely found in natural products and pharmaceuticals.The synthesis of these compounds not only provides insight into societal demands but also integrates cutting-edge research and theoretical knowledge taught in the classroom,thereby improving the quality of experimental teaching and achieving excellent educational outcomes.关键词
科教转化/综合有机化学实验/三唑并嘧啶类化合物/有机合成Key words
Transformation of science and education/Comprehensive organic chemistry experiment/Triazolopyrimidine compounds/Organic synthesis分类
社会科学引用本文复制引用
卢爱党,刘运亭,姜艳军..综合有机化学实验:三唑并嘧啶类化合物的合成与表征[J].大学化学,2024,39(8):241-246,6.基金项目
河北工业大学本科教育教学改革研究与实践项目(202201013) （202201013）
河北省高等教育教学改革研究与实践项目(2021GJJG032) （2021GJJG032）
河北省研究生课程思政建设项目(YKCSZ2022015) （YKCSZ2022015）
