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吲哚菁绿荧光成像在复杂腹腔镜胆囊切除术中的应用OACSTPCD

The application of indocyanine green fluorescence imaging in complex laparoscopic cholecystectomy

中文摘要英文摘要

目的:探讨吲哚菁绿(ICG)在复杂腹腔镜胆囊切除术(LC)中的临床应用价值及初步体会.方法:回顾分析2021年6 月至 2022 年 3 月为 70 例急性胆囊炎或有上腹部手术史的患者应用ICG行LC的临床资料.患者均经静脉注射ICG 5 mg,根据给药时间分为长时组(术前8~12h给药,n=36)与短时组(术前0.5~1 h给药,n=34).分析两组患者一般情况、实验室结果、术中荧光显影情况、手术时间等相关指标.结果:两组患者在性别、年龄、体重指数、美国麻醉医师协会评分及实验室结果等方面差异均无统计学意义(P>0.05).70 例患者中40 例(57.1%)显示胆囊管,65 例(92.9%)显示胆总管.两组胆囊荧光显影率、胆囊管荧光显影率、胆总管荧光显影率差异无统计学意义(P>0.05).短时组肝脏可视化率更高(P<0.001).两组手术难度评分、总手术时间差异无统计学意义(P>0.05).两组间显露胆囊三角时间差异无统计学意义(P=0.765),短时组从肝床剥离胆囊时间更短(P=0.026).结论:ICG应用于复杂LC的胆总管显影优于胆囊管.ICG辅助在胆囊三角的解剖中具有明显的指导作用.术前0.5~1 h给药在观察肝脏、从肝床剥离胆囊方面表现较好.因此,较短的给药时间可能更适于复杂LC.

Objective:To explore the clinical application value and preliminary experience of the indocyanine green (ICG) in complex laparoscopic cholecystectomy (LC). Methods:Clinical data of 70 patients who suffered from acute cholecystitis or a history of upper abdominal surgery and underwent LC using ICG from Jun. 2021 to Mar. 2022 were retrospectively analyzed. All patients were administered intravenously 5 mg ICG and divided into a long-term group (8~12 h before operation) and a short-term group (0. 5~1 h before operation) according to the time of administration. The general condition,laboratory results,intraoperative fluorescence visualization and operation time of the patients were analyzed. Results:The two groups showed no significant differences in sex,age,body mass index,American society of anesthesiologists score and laboratory results. In the 70 patients,40 (57. 1%) showed the cholecystic duct and 65 (92. 9%) showed the common bile duct. No significant differences were found between the two groups in the rates of gallbladder visualization,cystic duct visualization and common bile duct visualization (P>0. 05). The visualization rate of the liver in the short-term group was better than that in the long-term group (P<0. 001). No significant differences were found between the two groups in the operation difficulty score and total operation time (P>0.05). There were no statistical differences in gallbladder triangle exposure time (P=0. 765) between the two groups,whereas the gallbladder bed dissection time in the short-term group was shorter than that in the longterm group (P=0. 026). Conclusions:ICG-assisted complex LC can visualize the common bile duct better than the cystic duct. It has an obvious guiding role in the anatomy of gallbladder triangle. The administration 0. 5~1 h before operation is better in the visualization of the liver and the dissection of the gallbladder from the liver bed. So maybe the short duration of administration is more suitable for complex LC.

钟莹;吴昊钧;谭颖;梁梦萍;贾乾斌;刘自明;陈利平

四川大学华西医院上锦分院普外三科,四川 成都,610041四川大学华西医院胆道外科

临床医学

胆囊切除术,腹腔镜吲哚菁绿

Cholecystectomy,laparoscopicIndocyanine green

《腹腔镜外科杂志》 2024 (008)

602-606 / 5

四川大学华西医院学科卓越发展1.3.5工程临床研究孵化项目(2022HXFH007)

10.13499/j.cnki.fqjwkzz.2024.08.602

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