口腔疾病防治2024，Vol.32Issue(10)：797-804,8.DOI:10.12016/j.issn.2096-1456.202440197
牙龈卟啉单胞菌促进阿尔茨海默病的机制研究进展
Research progress on the potential mechanisms of Porphyromonas gingivalis in promoting Alzheimer's dis-ease
摘要
Abstract
Alzheimer's disease(AD),a common neurodegenerative disease,has been linked to periodontitis,espe-cially Porphyromonas gingivalis(P.gingivalis)infection.This review summarizes the potential mechanisms and path-ways through which P.gingivalis and its virulence factors are involved in AD pathogenesis,aiming to provide the scien-tific basis for the development of novel prevention and treatment strategies for AD.P.gingivalis can promote AD by ex-acerbating neuroinflammation,facilitating amyloid beta and Tau deposition,and disrupting the blood-brain barrier.Gin-gipains,secreted by P.gingivalis,serve as core effector molecules by increasing the blood-brain barrier permeability.The association between P.gingivalis and its effectors and AD pathology has been validated by metagenomic analysis and sample detection,indicating that P.gingivalis may be an environmental susceptibility factor or modifiable risk fac-tor for AD.However,the precise mechanisms by which P.gingivalis influences AD,and its interactions with other po-tential AD-related factors,remain unclear.Moreover,further research needs to be conducted on the therapeutic potential of P.gingvalis intervention in improving AD.关键词
牙龈卟啉单胞菌/阿尔茨海默病/牙龈蛋白酶/血脑屏障/牙周炎/神经退行性疾病/淀粉样β蛋白Key words
Porphyromonas gingivalis/Alzheimer's disease/gingipains/blood-brain barrier/periodontitis/neurodegenerative diseases/amyloid beta-protein分类
口腔医学引用本文复制引用
王玉洁,彭显,廖玍,周学东..牙龈卟啉单胞菌促进阿尔茨海默病的机制研究进展[J].口腔疾病防治,2024,32(10):797-804,8.基金项目
国家自然科学基金面上项目(32371523),四川省自然科学基金(2023NSFSC0558) This study was supported by the grants from the National Natural Science Foundation of China General Program(No.32371523)and the Natural Sciences Foundation of Sichuan Province(No.2023NSFSC0558). （32371523）
