Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healingOACSTPCD
Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound healing
Bacterial resistance and excessive inflammation are common issues that hinder wound healing.Antimicrobial peptides(AMPs)offer a promising and versatile antibacterial option compared to traditional antibiotics,with additional anti-inflammatory properties.However,the applications of AMPs are limited by their antimicrobial effects and stability against bacterial degradation.TFNAs are regarded as a promising drug delivery platform that could enhance the antibacterial properties and stability of nanodrugs.Therefore,in this study,a composite hydrogel(HAMA/t-GL13K)was prepared via the photocross-linking method,in which tFNAs carry GL13K.The hydrogel was injectable,biocompatible,and could be instantly photocured.It exhibited broad-spectrum antibacterial and anti-inflammatory properties by inhibiting the expression of inflammatory factors and scavenging ROS.Thereby,the hydrogel inhibited bacterial infection,shortened the wound healing time of skin defects in infected skin full-thickness defect wound models and reduced scarring.The constructed HAMA/tFNA-AMPs hydrogels exhibit the potential for clinical use in treating microbial infections and promoting wound healing.
Cai Qi;Qiang Sun;Dexuan Xiao;Mei Zhang;Shaojingya Gao;Bin Guo;Yunfeng Lin
State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,ChinaState Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology,Sichuan University,Chengdu,China||Sichuan Provincial Engineering Research Center of Oral Biomaterials,Chengdu,ChinaDepartment of Stomatology,The First Medical Centre,Chinese PLA General Hospital,Beijing,China
《国际口腔科学杂志（英文版）》 2024 (003)
436-447 / 12
This study was supported by National Key R&D Program of China(2019YFA0110600),National Natural Science Foundation of China(82370929,81970916),Sichuan Science and Technology Program(2022NSFSC0002),Sichuan Province Youth Science and Technology Innovation Team(2022JDTD0021),Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD03202302).We would like to thank Liying Hao(State Key Laboratory of Oral Diseases,West China Hospital of Stomatology,Sichuan University)for help in characterizing AFM.We acknowledge the support of the State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University.
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