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Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A.actinomycetemcomitans exacerbates arthritis

Tokuju Okano Miwa Sasai Masahiro Yamamoto Hiroshi Takayanagi Toshihiko Suzuki Hiroshi Ashida Noriko Komatsu Masayuki Tsukasaki Tamako Iida Marie Iwasawa Yuto Takahashi Yasuo Takeuchi Takanori Iwata

国际口腔科学杂志（英文版）2024，Vol.16Issue(3)：499-514,16.

国际口腔科学杂志（英文版）2024，Vol.16Issue(3)：499-514,16.DOI:10.1038/s41368-024-00315-x

Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A.actinomycetemcomitans exacerbates arthritis

Tokuju Okano ¹Miwa Sasai ²Masahiro Yamamoto ²Hiroshi Takayanagi ³Toshihiko Suzuki ¹Hiroshi Ashida ¹Noriko Komatsu ³Masayuki Tsukasaki ⁴Tamako Iida ¹Marie Iwasawa ¹Yuto Takahashi ¹Yasuo Takeuchi ⁵Takanori Iwata⁶

作者信息

1. Department of Bacterial Pathogenesis,Infection and Host Response,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo,Japan
2. Department of Immunoparasitology,Research Institute for Microbial Diseases,Osaka University,Osaka,Japan
3. Department of Immunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan
4. Department of Osteoimmunology,Graduate School of Medicine and Faculty of Medicine,The University of Tokyo,Tokyo,Japan
5. Department of Lifetime Oral Health Care Science,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo,Japan
6. Department of Periodontology,Graduate School of Medical and Dental Sciences,Tokyo Medical and Dental University,Tokyo,Japan
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摘要

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Tokuju Okano,Miwa Sasai,Masahiro Yamamoto,Hiroshi Takayanagi,Toshihiko Suzuki,Hiroshi Ashida,Noriko Komatsu,Masayuki Tsukasaki,Tamako Iida,Marie Iwasawa,Yuto Takahashi,Yasuo Takeuchi,Takanori Iwata..Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A.actinomycetemcomitans exacerbates arthritis[J].国际口腔科学杂志（英文版）,2024,16(3):499-514,16.

基金项目

We are grateful to Dr.Kawaguchi(University of Tokyo)for providing the mouse bone,Dr.Shibata,Dr.Saeki(Hokkaido University),Dr.Takeuchi(Tokyo Medical and Dental University)for providing the bacterial strains,and Dr.Tanaka(Niigata University)for providing the reagent.This study was supported by the Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science(15H04730,16H05186,16K08772,17K12004,19H03467,21J00572),a contract research fund from the Japan Program for Infectious Diseases Research and Infrastructure for research on emerging and re-emerging infectious diseases provided by the Japan Agency for Medical Research and Development(AMED),and the Project for Promoting Leading-edge Research in Oral Science at Tokyo Medical and Dental University. （University of Tokyo）

国际口腔科学杂志（英文版）

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