铁死亡在非小细胞肺癌机制特性及免疫微环境中作用的研究进展OA北大核心CSTPCD

Ferroptosis is a newly discovered cell death pattern characterized by pathway of reduction-oxidation in recent years.It is different from the classical pathways such as apoptosis,necrosis and autophagy in its mechanism and regulation of metabolism.With the in-depth study of tumor microenvironment and iron metabolism abnormalities in non-small cell lung cancer(NSCLC),ferroptosis has attracted extensive attention in the academic community.This paper focuses on the regulatory mechanism of ferrop-tosis in the development of NSCLC,the effects of ferroptosis on the biological characteristics of NSCLC cells,and the role of fer-roptosis in the immune microenvironment,aiming to further explore the possibility of ferroptosis as a clinical therapeutic target and provide new ideas for the development of therapeutic strategies for NSCLC.