海南医学院学报2024，Vol.30Issue(19)：1507-1513,7.DOI:10.13210/j.cnki.jhmu.20240508.001
铁死亡在非小细胞肺癌机制特性及免疫微环境中作用的研究进展
Research progress of ferroptosis in the mechanism and immune microenvironment of non-small cell lung cancer
摘要
Abstract
Ferroptosis is a newly discovered cell death pattern characterized by pathway of reduction-oxidation in recent years.It is different from the classical pathways such as apoptosis,necrosis and autophagy in its mechanism and regulation of metabolism.With the in-depth study of tumor microenvironment and iron metabolism abnormalities in non-small cell lung cancer(NSCLC),ferroptosis has attracted extensive attention in the academic community.This paper focuses on the regulatory mechanism of ferrop-tosis in the development of NSCLC,the effects of ferroptosis on the biological characteristics of NSCLC cells,and the role of fer-roptosis in the immune microenvironment,aiming to further explore the possibility of ferroptosis as a clinical therapeutic target and provide new ideas for the development of therapeutic strategies for NSCLC.关键词
铁死亡/非小细胞肺癌/肿瘤免疫/细胞生物学特性/调控机制Key words
Ferroptosis/Non-small cell lung cancer/Tumor immunity/Cell biological characteristics/Regulation mechanis分类
医药卫生引用本文复制引用
郭晓阳,曾凡,郑楷,李标..铁死亡在非小细胞肺癌机制特性及免疫微环境中作用的研究进展[J].海南医学院学报,2024,30(19):1507-1513,7.基金项目
This study was supported by Hainan Provincial Natural Science Foundation Project of 2022(822RC843) 2022年海南省自然科学基金项目(822RC843) （822RC843）
