口腔外甜味受体生物学作用的研究进展OA北大核心CSTPCD
Research progress on the biological role of extraoral sweet taste receptors
甜味受体(STR)是1型味觉受体的一种主要类型,可感知甜味并与不同的糖类和人工甜味剂相结合.虽然它最初被发现于口腔味蕾,但近来许多研究表明其在心脏、肾脏、胰腺、胃肠道、呼吸道和大脑等口腔外组织中均有表达,并发挥多种口外味觉效应,如参与摄食活动、能量稳态调节、内分泌代谢调节、内皮通透性调节、免疫防御调控和认知功能调节等.对此,本文综述STR的信号途径及其在口外组织中生物学作用的研究进展,旨在为STR相关的深入研究提供参考.
The sweet taste receptor(STR)is a critical member of type 1 taste receptors that senses sweetness and is activated by different types of saccharides and artificial sweeteners.Although it was originally discovered in oral taste buds,recent findings have demonstrated their expression in extraoral tissues such as the myocardium,kidneys,pancreas,gastrointestinal tract,respira-tory tract,and brain.They facilitate diverse biological functions,including the modulation of feeding activities,energy homeosta-sis,endocrine metabolism,endothelial permeability,immune defense,and cognitive function.In this review,the advancement in understanding the signaling pathways of STR and their biological roles in extraoral tissues was elucidated,aiming to provide a ref-erence for future research.
余善君;徐超群;唐香;周向东;李琪
海南医科大学第一附属医院呼吸内科,海南 海口 570102海南医科大学第一附属医院呼吸内科,海南 海口 570102||海南医科大学急诊与创伤学院,海南 海口 579199海南医科大学第一附属医院呼吸内科,海南 海口 570102||海南省呼吸疾病临床医学中心,海南 海口 570102
基础医学
甜味受体(sweet taste receptors,STR)信号途径生物学作用
Sweet taste receptor(STR)Signaling pathwayBiological role
《海南医学院学报》 2024 (019)
1514-1520 / 7
This study was supported by the National Natural Science Foundation of China(82260001,82160012);Major Science and Technology Special Projects in Hainan Province(ZDKJ2021036);Scientific and Technology Cooperation of Key Research and Development in Hainan Province(ZDYF2020223,GHYF2022011) 国家自然科学基金(82260001,82160012);海南省重大科技专项(ZDKJ2021036);海南省重点研发计划国际科技合作研究项目(ZDYF2020223,GHYF2022011)
评论