海南医学院学报2024，Vol.30Issue(19)：1514-1520,7.DOI:10.13210/j.cnki.jhmu.20240530.001
口腔外甜味受体生物学作用的研究进展
Research progress on the biological role of extraoral sweet taste receptors
摘要
Abstract
The sweet taste receptor(STR)is a critical member of type 1 taste receptors that senses sweetness and is activated by different types of saccharides and artificial sweeteners.Although it was originally discovered in oral taste buds,recent findings have demonstrated their expression in extraoral tissues such as the myocardium,kidneys,pancreas,gastrointestinal tract,respira-tory tract,and brain.They facilitate diverse biological functions,including the modulation of feeding activities,energy homeosta-sis,endocrine metabolism,endothelial permeability,immune defense,and cognitive function.In this review,the advancement in understanding the signaling pathways of STR and their biological roles in extraoral tissues was elucidated,aiming to provide a ref-erence for future research.关键词
甜味受体(sweet taste receptors,STR)/信号途径/生物学作用Key words
Sweet taste receptor(STR)/Signaling pathway/Biological role分类
医药卫生引用本文复制引用
余善君,徐超群,唐香,周向东,李琪..口腔外甜味受体生物学作用的研究进展[J].海南医学院学报,2024,30(19):1514-1520,7.基金项目
This study was supported by the National Natural Science Foundation of China(82260001,82160012) （82260001,82160012）
Major Science and Technology Special Projects in Hainan Province(ZDKJ2021036) （ZDKJ2021036）
Scientific and Technology Cooperation of Key Research and Development in Hainan Province(ZDYF2020223,GHYF2022011) 国家自然科学基金(82260001,82160012) （ZDYF2020223,GHYF2022011）
海南省重大科技专项(ZDKJ2021036) （ZDKJ2021036）
海南省重点研发计划国际科技合作研究项目(ZDYF2020223,GHYF2022011) （ZDYF2020223,GHYF2022011）
