河北医学2024，Vol.30Issue(9)：1545-1549,5.DOI:10.3969/j.issn.1006-6233.2024.09.025
甲状腺癌患者131 Ⅰ治疗前后CTC水平变化及临床意义
Changes and Clinical Significance of CTC Level in Patients with Thyroid Cancer before and after 131 Ⅰ Treatment
摘要
Abstract
Objective:To investigate the changes in peripheral blood circulating tumor cell(CTC)levels in patients with thyroid cancer before and after iodine radioisotope(131 Ⅰ)treatment and to analyze their clinical significance.Methods:A total of 108 patients with thyroid cancer who were treated with 131 Ⅰ in the hospital from January to December 2022 were selected as the study subjects.According to the prognosis after 12 months of treatment,the patients were divided into a metastasis group(19 cases)and a non-metastasis group(89 cases).CTC levels before and after treatment and general information of the two groups were comparative-ly analyzed.Logistic regression analysis was conducted to screen the prognostic factors.Results:CTC levels before and after treatment were(15.51±1.67)FR/mL and(8.50±2.30)FR/mL,with a statistically signifi-cant difference(P<0.05).The difference in CTC level in the non-metastasis group before and after treatment was significantly higher than in the metastasis group(P<0.05).There was no statistically significant differ-ence between the two groups in terms of age,gender,length of hospital stay,tumor type,tumor location,cap-sule invasion,T stage,residual thyroid mass,time from surgery to 131 Ⅰ treatment,frequency of 131 Ⅰ treatment,positive lymph nodes in the lateral cervical region,and Hashimoto's thyroiditis(P>0.05).The difference in the number of positive lymph nodes in the central cervical region was statistically significant(P<0.05).Lo-gistic regression analysis found that the number of positive lymph nodes in the central cervical region was an independent influencing factor for the recurrence and metastasis of thyroid cancer after 131 Ⅰ treatment.Conclu-sion:131 Ⅰ treatment after thyroidectomy can effectively improve CTC levels in patients with thyroid cancer,and the improvement of CTC levels before and after treatment is lower in patients with recurrence and metastasis.CTC helps predict recurrence and metastasis after thyroidectomy combined with 131 Ⅰ treatment.The number of positive lymph nodes in the central cervical region is an independent influencing factor for the recurrence and metastasis of thyroid cancer after 131 Ⅰ treatment.关键词
甲状腺癌/放射性碘同位素/外周血循环肿瘤细胞Key words
Thyroid cancer/Iodine radioisotope/Peripheral blood circulating tumor cell引用本文复制引用
段俊,徐海青,鲁树华..甲状腺癌患者131 Ⅰ治疗前后CTC水平变化及临床意义[J].河北医学,2024,30(9):1545-1549,5.基金项目
2022年安徽省重点研究与开发计划项目,(编号:2022e07020056) （编号:2022e07020056）
