河北医学2024，Vol.30Issue(9)：1572-1577,6.DOI:10.3969/j.issn.1006-6233.2024.09.030
门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病患者疗效及对血清NRG4 HGF SAA水平胰岛细胞功能的影响
Efficacy of Insulin Aspart Combined with Insulin Detemir in the Treatment of Patients with GDM and the Effect on Serum NRG4,HGF and SAA Levels and Islet Cell Function
摘要
Abstract
Objective:To investigate the efficacy of insulin aspart combined with insulin detemir in the treatment of GDM and the effect on serum neuregulin 4(NRG4),HGF,and amyloid A(SAA)levels and is-let cell function.Methods:From June 2020 to June 2023,113 patients with GDM were selected and randomly divided into the control group(n=56)and the observation group(n=57).The control group was treated with insulin aspart combined with premixed protamine recombinant human insulin while the observation group was treated with insulin aspart combined with insulin detemir.The two groups were compared on insulin use,time to blood glucose reaching the standard,blood glucose indicators(FBG,2hPBG,and HbA1c),serum NRG4,HGF and SAA levels,islet cell function indicators[HOMA-IR,Homeostasis Model Assessment of beta-cell(HOMA-β)and fasting insulin(FINS)]and pregnancy outcomes.Results:The dosage of insulin and injec-tion frequency in the observation group were lower than in the control group,and the time to blood glucose reaching the standard was shorter than that in the control group(P<0.05).The differences in FBG,2hPBG,HbA1c,serum NRG4,HGF and SAA levels,HOMA-β,HOMA-IR,and FINS before and after treatment in the observation group were greater than those in the control group(all P<0.05).There was no statistically significant difference in the incidence rates of cesarean section,fetal macrosomia,neonatal hypoglycemia,and fetal distress between the two groups(P>0.05).Conclusion:The combined treatment with insulin aspart and insulin detemir has a significant therapeutic effect on GDM,which can control blood glucose,shorten the time for blood glucose to reach the standard,and improve serum NRG4,HGF,and SAA levels as well as islet cell function.关键词
妊娠期糖尿病/门冬胰岛素/地特胰岛素/神经调节蛋白4/肝细胞生长因子/淀粉样蛋白A/胰岛细胞功能Key words
Gestational diabetes mellitus/Insulin aspart/Insulin detemir/Neuregulin 4/Hepatocyte growth factor/Amyloid A/Islet cell function引用本文复制引用
邵晓洁,朱捷,孔玲玲,管文婕,杨洋,李健..门冬胰岛素联合地特胰岛素治疗妊娠期糖尿病患者疗效及对血清NRG4 HGF SAA水平胰岛细胞功能的影响[J].河北医学,2024,30(9):1572-1577,6.基金项目
安徽省自然科学基金项目,(编号:200809QH40) （编号:200809QH40）
