结核与肺部疾病杂志2024，Vol.5Issue(5)：484-488,5.DOI:10.19983/j.issn.2096-8493.2024097
miR-451a调控TLR4信号通路在结核病发病中的研究进展
Research progress on the regulation of TLR4 signaling pathway by miR-451a in the pathogenesis of tuberculosis
摘要
Abstract
MicroRNAs(miRNAs)play a pivotal role in immune regulation and inflammatory responses,contributing to the onset and progression of various diseases.miR-451a,a specific microRNA,is predominantly expressed in erythroid precursors and has been implicated in the pathogenesis of hematological disorders such as leukemia,as well as in non-hematological diseases including congenital heart disease,esophageal cancer,multiple myeloma,and sepsis.Furthermore,miR-451a modulates the TLR4 signaling pathway,thereby influencing the pathogenesis of tuberculosis.The authors investigated the mechanism by which miR-451a regulates the TLR4 signaling pathway,with the goal of examining recent advancements in understanding the role of miR-451a in tuberculosis pathogenesis.This study aims to provide novel theoretical insights for the identification of potential targets in anti-tuberculosis drug development.关键词
微RNAs/信号传导/结核/综述文献(主题)Key words
MicroRNAs/Signal transduction/Tuberculosis/Review literature as topic分类
医药卫生引用本文复制引用
赵菲,詹璐..miR-451a调控TLR4信号通路在结核病发病中的研究进展[J].结核与肺部疾病杂志,2024,5(5):484-488,5.基金项目
Hangzhou Medical and Health Technology Project(ZD20210032) 杭州市医药卫生科技项目(ZD20210032) （ZD20210032）
