华侨大学学报（自然科学版）2024，Vol.45Issue(5)：551-558,8.DOI:10.11830/ISSN.1000-5013.202407001
超临界CO2流体技术制备脱细胞外基质材料及其生物医学应用
Supercritical CO2 Fluid Technology-Assisted Fabrication of Decellularized Extracellular Matrix Materials and Biomedical Applications
摘要
Abstract
Decellularized extracellular matrix(dECM)materials play a significant role in tissue engineering and regenerative medicine.Supercritical CO2 fluid(SCF-CO2)technology has been proven to be applicable in the preparation of dECM materials.By reviewing relevant literature in recent years,this paper summarizes the basic principles of SCF-CO2,the mechanisms of decellularization and sterilization by SCF-CO2,and discusses the impact of auxiliary solvents and pretreatment techniques on SCF-CO2-assisted decellularization,as well as the biomedical applications of dECM materials.The results show that,compared with conventional methods,SCF-CO2 with high permeability and high diffusivity could maintain the structural integrity and biological activ-ity of extracellular matrix(ECM)more effectively and show the advantage of high sterilization efficiency.Mo-reover,the prepared dECM materials have significant potential for application in the field of tissue repair and regenerative medicine.关键词
超临界CO2流体/脱细胞外基质/超临界灭菌/组织工程Key words
supercritical carbon dioxidefluid/decellularized extracellular matrix/supercritical sterilization/tissue engineering分类
医药卫生引用本文复制引用
吴冰,段又愈,陈爱政..超临界CO2流体技术制备脱细胞外基质材料及其生物医学应用[J].华侨大学学报（自然科学版）,2024,45(5):551-558,8.基金项目
国家自然科学基金面上资助项目(32271410) （32271410）
