维生素B6的合成代谢及其生产应用OACSTPCD
Synthesis Metabolism and Production Application of Vitamin B6
为了得到环保、便捷且效率更高的维生素B6代谢生产途径,综述了维生素B6作为重要的生物活性小分子在不同生物体中参与的天然合成代谢途径及目前研究发现的偶然代谢途径;同时,总结了利用生物酶法与代谢工程生产维生素B6的生物合成法.结果表明:通过生物合成维生素B6可以代替化学合成法,但未来仍需要研究者对代谢途径进行不断优化、筛选,以得到更高产量的维生素B6.
In order to achieve an environmentally friendly,convenient,and more efficient metabolic produc-tion pathway for vitamin B6,the natural metabolic and serendipitous pathways of vitamin B6 as an important bioactive small molecule in various organisms are comprehensively reviewed.Additionally,the biosynthesis method of vitamin B6 production by enzyme and metabolic engineering techniques is summarized.The results indicate that biosynthesis can serve as an alternative method to chemical synthesis for producing vitamin B6.However,further research is needed to continuously optimize and screen the metabolic pathway to obtain high-er yields of vitamin B6.
李丹妮;郑忠亮
武汉大学生命科学学院,湖北武汉 430072
生物学
维生素B6系统代谢工程偶然途径酶催化
vitamin B6system metabolic engineeringserendipitous pathwayenzyme catalysis
《华侨大学学报（自然科学版）》 2024 (005)
588-595 / 8
国家自然科学基金资助项目(30800190,81372441)
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