解放军医学杂志2024，Vol.49Issue(9)：998-1003,6.DOI:10.11855/j.issn.0577-7402.1273.2024.0717
NT-proBNP与急进高原人群心肺适能的相关性分析
Correlation between the level of NT-proBNP and cardiorespiratory fitness of individuals following acute high altitude exposure
摘要
Abstract
Objective To investigate the correlation between the level of N-terminal pro-Brain natriuretic peptide(NT-proBNP)and cardiorespiratory fitness following acute exposure to high altitude.Methods Forty-six subjects were recruited from the Second Affiliated Hospital of Army Medical University in June 2022,including 19 males and 27 females.After completing cardiopulmonary exercise test(CPET),serological detection of myocardial cell-related markers,and multiple metabolites at a plain altitude(300 meters above sea level),all subjects flew to a high-altitude location(3900 meters above sea level).Biomarker testing and CPET were repeated on the second and third days after arrival at high altitude.Changes in serum biomarker and key CPET indicators before and after rapid ascent to high altitude were compared,and the correlation between serum levels of various myocardial cell-related markers and metabolites and high altitude cardiorespiratory fitness was analyzed.Results Compared with the plain altitude,there was a significant decrease in maximal oxygen uptake after rapid ascent to high altitude[(25.41±6.20)ml/(kg.min)vs.(30.17±5.01)ml/(kg.min),P<0.001].Serum levels of NT-proBNP,Epinephrine(E),plasma renin activity(PRA),angiotensin Ⅱ(Ang Ⅱ),angiotensin-converting enzyme 2(ACE2)and leptin(LEP)significantly increased,with all differences being statistically significant(P<0.05)after acute high altitude exposure.In contrast,no statistically significant differences were observed for creatine kinase MB(CK-MB),cardiac troponin I(cTnI),myoglobin(Myo)and norepinephrine(NE)(P>0.05).Correlation analysis showed a significant negative correlation between NT-proBNP at plain altitude(r=-0.768,P<0.001)and at high altitude(r=-0.791,P<0.001)with maximal oxygen uptake at high altitude.Multivariate linear regression analysis indicated that maximal oxygen uptake at plain altitude(t=2.069,P=0.045),NT-proBNP at plain altitude(t=-2.436,P=0.020)and at high altitude(t=-3.578,P=0.001)were independent influencing factors of cardiorespiratory fitness at high altitude.Conclusion Cardiorespiratory fitness significantly decreases after rapid ascent to high altitude,and the baseline NT-proBNP level at plain altitude is closely related to cardiorespiratory fitness at high altitude,making it a potential predictor indicator for high altitude cardiorespiratory fitness.关键词
心肺适能/高原/氨基末端脑钠肽前体/心肺运动试验Key words
cardiorespiratory fitness/high altitude/N-terminal pro-Brain natriuretic peptide/cardiopulmonary exercise test分类
医药卫生引用本文复制引用
李平平,吕海霖,贾倩羽,杨媛淇,杨冰洁,黄岚,叶筱葳,杨杰,秦浙学,卞士柱,张继航,高旭滨,孙梦佳,刘振..NT-proBNP与急进高原人群心肺适能的相关性分析[J].解放军医学杂志,2024,49(9):998-1003,6.基金项目
This work was supported by the Subject Excellence Program of the Second Affiliated Hospital of Army Medical University(2022D008) 陆军军医大学第二附属医院学科优才项目(2022D008) （2022D008）
