知母-黄柏对D-gal认知功能障碍模型小鼠海马神经元细胞异常自噬的影响OA北大核心CSTPCD
Effect of Rhizoma-Anemarrhenae-Cortex Phellodendri on abnormal autophagy of hippocampal neurons in D-gal cognitive impairment model mice
目的:通过观察海马内自噬相关蛋白的表达水平探讨知母-黄柏药对(AP)改善D-半乳糖(D-gal)模型小鼠认知功能障碍的作用机制.方法:75只小鼠随机分为空白组、模型组、吡拉西坦组、AP组,自噬诱导剂依维莫司(RAD001)组,除空白组腹腔注射生理盐水外,其余各组均注射0.125 g∙kg-1∙d-1 的D-gal以复制认知功能障碍模型.通过水迷宫实验测试小鼠认知功能障碍情况,HE染色及尼氏染色法观察各组小鼠海马组织神经元状态以及尼氏小体数量,免疫…查看全部>>
Objective:To explore the mechanism of Rhizoma Anemarrhenae-Cortex Phellodendri(AP)in ameliorating cogni-tive dysfunction in D-galactose(D-gal)model mice by observing the expression level of autophagy-related proteins in the hippo-campus.Methods:Seventy-five mice were randomly divided into blank group,model group,piracetam group,AP group and au-tophagy inducer everolimus(RAD001)group.Except for the blank group,all the other groups were injected with 0.125 g∙k…查看全部>>
刘宇欣;王雅梦;成思敏;朱紫悦;金美玲;赵德萍;徐红丹;雷霞;张宁
黑龙江中医药大学,黑龙江 哈尔滨 150040黑龙江中医药大学,黑龙江 哈尔滨 150040黑龙江中医药大学,黑龙江 哈尔滨 150040黑龙江中医药大学,黑龙江 哈尔滨 150040黑龙江中医药大学,黑龙江 哈尔滨 150040黑龙江中医药大学,黑龙江 哈尔滨 150040无锡卫生高等职业技术学校,江苏 无锡 214028南京中医药大学无锡附属医院,江苏省中医退行性骨关节病临床医学创新中心,江苏 无锡 214071黑龙江中医药大学,黑龙江 哈尔滨 150040||南京中医药大学无锡附属医院,江苏省中医退行性骨关节病临床医学创新中心,江苏 无锡 214071
中医学
知母-黄柏药对(AP)D-gal模型认知功能障碍自噬
Rhizoma Anemarrhenae-Cortex Phellodendri Pair of drugs(AP)D-gal modelCognitive dysfunctionAutoph-agy
《海南医学院学报》 2024 (19)
1459-1467,9
This study was supported by National Natural Science Foundation of China(82174007)and Wuxi Health Commission Young and Middle-Aged Top Talent Funding Program(2023072) 国家自然科学基金面上项目(82174007)无锡市卫生健康委中青年拔尖人才资助计划(2023072)
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