实用临床医药杂志2024，Vol.28Issue(17)：127-130,4.DOI:10.7619/jcmp.20241523
缺氧诱导因子1α在肝细胞癌靶点治疗中的研究进展
Research progress on hypoxia-inducible factor 1αin targeted therapy for hepatocellular carcinoma
摘要
Abstract
Novel therapeutic approaches targeting key genes and regulatory molecules of hepato-cellular carcinoma(HCC)have gradually been carried out in clinical practice.Hypoxia-inducible factor(HIF),as a critical factor for hepatocellular carcinoma cells to adapt to the hypoxic microenvi-ronment,mediates changes in the transcription of many genes.HIF has a wide range of target genes and can promote metabolic reprogramming,angiogenesis,invasion and metastasis,and immune es-cape of cancer cells by regulating various signaling pathways.Hypoxia-inducible factor 1α(HIF-1α),as the main member of the HIF family,can provide new ideas and insights for exploring potential tar-gets for HCC treatment.关键词
缺氧诱导因子/肝细胞癌/缺氧诱导因子1αKey words
hypoxia-inducible factor/hepatocellular carcinoma/hypoxia-inducible factor 1 α分类
医药卫生引用本文复制引用
黄丽恒,林洪升,邓增富,杨利,李明芬..缺氧诱导因子1α在肝细胞癌靶点治疗中的研究进展[J].实用临床医药杂志,2024,28(17):127-130,4.基金项目
广西自然科学基金资助项目(2023GXNSFAA026278) （2023GXNSFAA026278）
