实用临床医药杂志2024，Vol.28Issue(18)：47-50,4.DOI:10.7619/jcmp.20241906
维持性血液透析患者血清细胞分裂周期蛋白42、β2微球蛋白、腓骨蛋白1水平与腹主动脉钙化的相关性
Correlations of serum cell division cycle 42,β2-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis
摘要
Abstract
Objective To investigate the correlations of serum cell division cycle 42(CDC-42),β2-microglobulin(β2-MG)and fibulin 1(FBLN1)levels with abdominal aortic calcification(AAC)in patients with maintenance hemodialysis(MHD).Methods General information and bio-chemical indicators of 74 MHD patients were collected,and they were divided into no to mild AAC group(n=36)and moderate to severe AAC group(n=38)based on the Abdominal Aortic Calcifi-cation Score(AACs).Serum levels of CDC-42,β2-MG and FBLN1 were compared between the two groups,and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients.Results The dialysis vintage,serum phosphorus,intact parathyroid hormone(iPTH),CDC-42,β2-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group(P＜0.05).AAC in MHD patients was positively cor-related with serum phosphorus,iPTH,CDC-42,β2-MG,FBLN1,and dialysis vintage(P＜0.05).High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage were independent risk fac-tors for AAC in MHD patients(P＜0.05).Conclusion Serum CDC-42,β2-MG and FBLN1 levels are positively correlated with AAC in MHD patients.High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.关键词
维持性血液透析/细胞分裂周期蛋白42/β2微球蛋白/腓骨蛋白1/腹主动脉钙化/相关性Key words
maintenance hemodialysis/cell division cycle 42/β2-microglobulin/fibulin 1/abdominal aortic calcification/correlation分类
医药卫生引用本文复制引用
闫军放,宗茜,袁亮,包婷,许雯婷..维持性血液透析患者血清细胞分裂周期蛋白42、β2微球蛋白、腓骨蛋白1水平与腹主动脉钙化的相关性[J].实用临床医药杂志,2024,28(18):47-50,4.基金项目
安徽省自然科学基金项目(2308085QH255) （2308085QH255）
安徽医科大学校科研基金项目(2018xkj031) （2018xkj031）
