维持性血液透析患者血清细胞分裂周期蛋白42、β2微球蛋白、腓骨蛋白1水平与腹主动脉钙化的相关性OACSTPCD

Objective To investigate the correlations of serum cell division cycle 42(CDC-42),β2-microglobulin(β2-MG)and fibulin 1(FBLN1)levels with abdominal aortic calcification(AAC)in patients with maintenance hemodialysis(MHD).Methods General information and bio-chemical indicators of 74 MHD patients were collected,and they were divided into no to mild AAC group(n=36)and moderate to severe AAC group(n=38)based on the Abdominal Aortic Calcifi-cation Score(AACs).Serum levels of CDC-42,β2-MG and FBLN1 were compared between the two groups,and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients.Results The dialysis vintage,serum phosphorus,intact parathyroid hormone(iPTH),CDC-42,β2-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group(P＜0.05).AAC in MHD patients was positively cor-related with serum phosphorus,iPTH,CDC-42,β2-MG,FBLN1,and dialysis vintage(P＜0.05).High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage were independent risk fac-tors for AAC in MHD patients(P＜0.05).Conclusion Serum CDC-42,β2-MG and FBLN1 levels are positively correlated with AAC in MHD patients.High levels of CDC-42,β2-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.