实用临床医药杂志2024，Vol.28Issue(18)：68-75,80,9.DOI:10.7619/jcmp.20240283
血清胱抑素C和超敏C反应蛋白对维持性血液透析患者3年生存情况的影响分析
Impact of serum cystatin C and hypersensitivity C-reactive protein on the 3-year survival of patients undergoing maintenance hemodialysis
摘要
Abstract
Objective To investigate the influence of serum cystatin C(Cys-C)and hypersensi-tivity C-reactive protein(hs-CRP)levels on the 3-year survival of patients undergoing maintenance he-modialysis(MHD).Methods A total of 358 patients with chronic renal failure who underwent MHD at the Second Affiliated Hospital of Nantong University from April 2011 to October 2020 were selected as study subjects.General clinical data,pre-dialysis laboratory test indicators,and echocardiographic indicators 3 months after dialysis were recorded.The survival status of patients after 3 years of dialysis was followed up,and the general clinical data,pre-dialysis laboratory test indicators,and echocardio-graphic indicators 3 months after dialysis were compared between surviving and deceased patients.Un-ivariate and multivariate Cox regression analyses were performed to screen influencing factors of 3-year survival in MHD patients.Results At the 3-year follow-up,of the 302 MHD patients'203 survived,and 99 died.Statistically significant differences were observed in age,primary disease,diabetes sta-tus,congestive heart failure,statin use,antiplatelet drug use,diuretic use,dialysis mode,esti-mated glomerular filtration rate(eGFR)and gamma-glutamyl transferase(GGT),alkaline phospha-tase(AKP),total bilirubin(TBIL),β2-microglobulin(β2-MG),creatinine(Cr),low-density lipoprotein cholesterol(LDL-C),hypersensitive C-reactive protein(hs-CRP),and serum phos-phorus(P)levels between surviving patients and deaths(P＜0.05 or P＜0.01).Univariate Cox regression results showed that age of MHD patients,primary disease(diabetic nephropathy,hyper-tensive nephropathy,polycystic kidney disease,others),comorbidities(diabetes,congestive heart failure,other cardiovascular diseases),drug use(statins,antiplatelet drugs),dialysis method(he-modialysis,hemodialysis+perfusion),laboratory test indicators[GGT,AKP,TBIL,total bile acid(TBA),albumin(ALB),Cr,Cys-C,eGFR,apolipoprotein A(APO-A),hs-CRP]were all influential factors of 3-year survival rate of MHD patients.Multivariate Cox regression analysis re-vealed that age,primary disease,other cardiovascular diseases,dialysis mode,AKP,ALB,TBIL,Cys-C,and hs-CRP were significant influencing factors for the survival of patients with chronic renal failure(P＜0.05).Conclusion Serum Cys-C and hs-CRP levels before MHD in patients with chronic renal failure may be associated with their 3-year survival after dialysis treatment.High serum Cys-C may reduce the risk of poor clinical prognosis,while high serum hs-CRP may increase the risk of poor clinical prognosis.关键词
慢性肾衰竭/维持性血液透析/胱抑素C/超敏C反应蛋白/临床预后Key words
chronic renal failure/maintenance hemodialysis/cystatin C/hypersensitivity C-reactive protein/clinical prognosis分类
医药卫生引用本文复制引用
姚斌斌,沈燕,杨红丽,冯素娟,黄华星,朱雪玲,沈良兰..血清胱抑素C和超敏C反应蛋白对维持性血液透析患者3年生存情况的影响分析[J].实用临床医药杂志,2024,28(18):68-75,80,9.基金项目
江苏省中医药科技发展计划项目(MS2021060) （MS2021060）
2022年度江苏省南通市基础科学研究和社会民生科技计划项目(MSZ2022011) （MSZ2022011）
江苏省南通市卫生健康委员会科研课题项目(MS2023034) （MS2023034）
江苏省南通市基础科学研究面上项目(JC22022008) （JC22022008）
