实用临床医药杂志2024，Vol.28Issue(18)：76-80,5.DOI:10.7619/jcmp.20241618
尿肝脏型脂肪酸结合蛋白、血清半乳糖凝集素3与痛风患者早期肾功能损伤的相关性研究
Relationships of urinary liver-type fatty acid-binding protein and serum galectin-3 with early renal dysfunction in gout patients
摘要
Abstract
Objective To investigate the relationships of urinary liver-type fatty acid-binding pro-tein(L-FABP)and serum galectin-3(Gal-3)with early renal dysfunction in gout patients.Methods A total of 124 gout patients in the hospital from January 2022 to December 2023 were selected as gout group,and they were divided into non-renal injury group with 42 cases and early renal injury group with 82 cases according to the urinary albumin-to-creatinine ratio(UACR).Additionally,40 healthy volunteers with physical examinations in the hospital in the same period were selected as control group.The levels of urea nitrogen,creatinine,cystatin C,urinary L-FABP,and serum Gal-3 were measured in all participants.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of urinary L-FABP and serum Gal-3 for early renal dysfunction in gout patients.Results The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the gout group were significantly higher than those in the control group(P＜0.05).The levels of cystatin C,urinary L-FABP,and serum Gal-3 in the early renal injury group were significantly higher than those in the non-renal injury group(P＜0.05).Pearson analysis showed that urinary L-FABP level in gout patients was significantly positively correlated with UACR,cystatin C,and serum Gal-3(P＜0.05),and serum Gal-3 level in gout pa-tients was significantly positively correlated with UACR,cystatin C,and urinary L-FABP(P＜0.05).ROC curve analysis indicated that urinary L-FABP and serum Gal-3 had high diagnostic values for assessing early renal dysfunction in gout patients,with areas under the curve(AUCs)of 0.804(95％CI,0.726 to 0.882)and 0.781(95％CI,0.697 to 0.866)respectively.The AUC for the combination of urinary L-FABP and serum Gal-3 was 0.923(95％CI,0.874 to 0.972).Conclu-sion The levels of urinary L-FABP and serum Gal-3 are abnormally elevated in gout patients,and their expression levels are closely related to early renal dysfunction.The combination of urinary L-FABP and serum Gal-3 has a high diagnostic value for early renal dysfunction in gout patients.关键词
痛风/肾功能/肝脏型脂肪酸结合蛋白/半乳糖凝集素-3Key words
gout/renal function/liver-type fatty acid-binding protein/galectin-3分类
医药卫生引用本文复制引用
朱咏梅,杜琳,王丹..尿肝脏型脂肪酸结合蛋白、血清半乳糖凝集素3与痛风患者早期肾功能损伤的相关性研究[J].实用临床医药杂志,2024,28(18):76-80,5.基金项目
陕西省科技计划项目(2022D045) （2022D045）
