摘要
Abstract
Objective To investigate the relationship between serum periostin(POSTN)level and bone mineral density in patients undergoing maintenance hemodialysis(MHD).Methods Nine-ty-five patients who had received MHD treatment for more than 3 months in the Hemodialysis Center of Qingdao Municipal Hospital from October 2022 to October 2023 were enrolled as experimental group.Meanwhile,50 healthy individuals undergoing health examinations in the Physical Examination Center of the same hospital during the same period were selected as the control group.Clinical data such as gender and age were collected for both groups.Fasting venous blood samples were collected before di-alysis to measure parathyroid hormone(PTH),alkaline phosphatase(ALP),urea nitrogen,serum creatinine,serum calcium,serum phosphorus,and other indicators.Serum POSTN levels in MHD pa-tients and healthy individuals were determined using enzyme-linked immunosorbent assay(ELISA).The correlation between serum POSTN levels and bone mineral density in MHD patients was explored.Univariate and multivariate binary Logistic regression analyses were performed to identify risk factors for low bone mineral density in MHD patients and assess the clinical value of serum POSTN level in predicting low bone mineral density in these patients.Results The serum POSTN level in the experi-mental group were significantly higher than those in the control group(P＜0.05).These patients were divided into two groups based on T-values:normal bone mass group(47 cases,T value＞-1.0)and low bone mineral density(48 cases,T value≤-1.0).The low bone mineral density group had significantly higher serum POSTN levels,dialysis vintage,PTH,ALP,serum phosphorus,β2-micro-globulin levels,and a higher proportion of females compared to the normal bone mass group(P＜0.05).Pearson correlation analysis revealed negative correlations of bone mineral density T values with serum POSTN,dialysis vintage,C-reactive protein,PTH,ALP,serum phosphorus,and β2-mi-croglobulin in MHD patients(r=-0.695,-0.688,-0.246,-0.528,-0.216,-0.309,-0.293;P＜0.05).Multivariate binary Logistic regression analysis showed that after adjusting for confounding factors such as dialysis vintage,PTH,and ALP,high serum POSTN level was an inde-pendent risk factor for low bone mineral density in MHD patients.The receiver operating character-istic(ROC)curve indicated that the area under the curve(AUC)for serum POSTN level in predic-ting low bone mineral density in MHD patients was 0.901,with a cut-off value of 29.66 ng/L.Conclusion MHD patients have higher serum POSTN levels than healthy individuals,and this marker is associated with low bone mineral density in MHD patients.关键词
维持性血液透析/骨膜素/骨密度/慢性肾脏病矿物质与骨异常/慢性肾脏病/终末期肾脏病Key words
maintenance hemodialysis/periostin/bone mineral density/chronic kidney dis-ease-mineral and bone disorder/chronic kidney disease/end-stage renal disease分类
医药卫生
