芍药苷调节SIRT1/PGC-1α/Nrf2信号通路对过氧化氢诱导皮肤成纤维细胞氧化应激损伤的影响OACSTPCD
Effect of Paeoniflorin on Hydrogen Peroxide-Induced Oxidative Stress Damage in Skin Fibroblasts by Regulating the SIRT1/PGC-1α/Nrf2 Signaling Pathway
目的:探讨芍药苷(PF)调节沉默信息调节因子 2 同系物 1(SIRT1)/氧化物酶体增殖物激活受体γ共激活剂-1α(PGC-1α)/核因子E2 相关因子2(Nrf2)信号通路对过氧化氢(H2O2)诱导皮肤成纤维细胞(HSF)氧化应激损伤的影响.方法:以 HSF 细胞为研究对象,将其分为 Control 组、H2O2组、L-PF、M-PF、H-PF组、PF+EX527 组;CCK-8 检测 HSF 细胞增殖;β-半乳糖苷酶染色法检测 HSF细胞衰…查看全部>>
Objective:To investigate the effect of paeoniflorin(PF)on oxidative stress damage induced by hydrogen peroxide(H2O2)in skin fibroblasts(HSF)by regulating the silent information regulator 2 homo-logue 1(SIRT1)/peroxisome proliferator activated receptor-gamma coactivator-1α(PGC-1α)/nuclear fac-tor erythroid-derived 2-related factor 2(Nrf2)signaling pathway.Methods:HSF cells were studied and sep-arated into the Control group,H2O2 group,L-PF,M-PF,H-PF group,and …查看全部>>
黄燕;杨艳清;周进飞
湖北省武汉市第三医院整形外科,湖北 武汉 430060湖北省武汉市第三医院整形外科,湖北 武汉 430060湖北省襄阳市伊莱美医疗美容门诊部,湖北 襄阳 441000
芍药苷沉默信息调节因子2同系物1氧化物酶体增殖物激活受体γ共激活剂-1α核因子E2相关因子2皮肤成纤维细胞氧化应激损伤
PaeoniflorinSilent information regulator 2 homologue 1Peroxisome proliferator ac-tivated receptor-gamma coactivator-1αNuclear factor erythroid-derived 2-related factor 2Skin fibro-blastsOxidative stress damage
《河北医学》 2024 (9)
1428-1434,7
湖北省武汉市医学科研项目立项任务书,(编号:WX20Q03)
评论