实用临床医药杂志2024，Vol.28Issue(17)：15-19,26,6.DOI:10.7619/jcmp.20242187
C反应蛋白与白蛋白比值联合握力和血清前白蛋白在食管癌患者中的应用价值
Application value of C-reactive protein to albumin ratio combined with grip strength and serum prealbumin in patients with esophageal cancer
摘要
Abstract
Objective To investigate the predictive value of the C-reactive protein to albumin ratio(CAR)combined with grip strength and serum prealbumin for survival and malnutritionin pa-tients with esophageal cancer.Methods A total of 212 patients with esophageal cancer were selected as study objects,and baseline characteristics,pretreatment CAR,grip strength,and serum prealbu-min results were collected.Nutritional status was assessed,and overall survival was followed up.Re-ceiver operating characteristic(ROC)curves were used to evaluate the predictive value of pretreatment CAR,grip strength,and serum prealbumin for malnutrition.Kaplan-Meier survival curves and Cox re-gression models were employed to analyze their predictive value for survival outcomes.Results ROC curve analysis revealed that grip strength had the largest area under the curve(0.625)for predicting malnutritionin esophageal cancer patients,followed by serum prealbumin and CAR(0.604,0.594).Based on the Youden index,the optimal cut-off values for CAR,grip strength,and serum prealbumin were 0.732,23.1 kg,and 0.190 g/L,respectively.The sensitivity of the combined detection of three indicators was 80.7％.Kaplan-Meier survival curve analysis showed that patients with elevated CAR(≥0.732),reduced grip strength(＜23.1 kg),and decreased serum prealbumin levels(＜0.190 g/L)had shorter overall survival compared to those with CAR＜0.732,grip strength ≥23.1 kg,and serum prealbumin levels ≥0.190 g/L,respectively(P＜0.01).Multivariate Cox regression analysis identi-fied elevated pretreatment CAR(≥0.732),reduced grip strength(＜23.1 kg),and decreased ser-um prealbumin levels(＜0.190 g/L)as independent risk factors for poor survival prognosis in esoph-ageal cancer patients(P＜0.05).Conclusion Pretreatment CAR,grip strength,and serum preal-bumin are important indicators for assessing nutritional status and survival prognosis in esophageal cancer patients.Combined detection of these biomarkers may facilitate early diagnosis and timely in-tervene malnutrition,potentially improving survival outcomes in esophageal cancer patients.关键词
食管癌/C反应蛋白与白蛋白比值/握力/血清前白蛋白/营养状态/预后Key words
esophageal cancer/C-reactive protein to albumin ratio/grip strength/serum prealbumin/nutritional status/prognosis分类
医药卫生引用本文复制引用
彭顺仙,陶花,陈晓锋,彭纪芳,蒋书娣..C反应蛋白与白蛋白比值联合握力和血清前白蛋白在食管癌患者中的应用价值[J].实用临床医药杂志,2024,28(17):15-19,26,6.基金项目
南京医科大学肿瘤护理研究分中心开放课题项目(NYZLKF-2-202121) （NYZLKF-2-202121）
