茶黄素调节PI3K/Akt/mTOR信号通路对A549细胞增殖凋亡及自噬的影响OACSTPCD
Effects of Theaflavin on Proliferation Apoptosis and Autophagy of A549 Cell by Regulating the PI3K/Akt/mTOR Signaling Pathway
目的:探讨茶黄素调节磷脂酰肌醇 3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路对A549 细胞增殖、凋亡及自噬的影响.方法:测定 0、2.5、5、10、20、40、80、160μmoL/L茶黄素干预A549 细胞后增殖率,筛选出合适的作用浓度.将 A549 细胞分为 control 组、低-茶黄素组(20μmoL/L茶黄素)、中-茶黄素组(40μmoL/L茶黄素)、高-茶黄素组(80μmoL/L茶黄素)、高…查看全部>>
Objective:To investigate the effects of theaflavin on A549 cell proliferation,apoptosis,and autophagy by regulating the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian tar-get of rapamycin(mTOR)signaling pathway.Methods:The proliferation rate of A549 cells was measured af-ter intervention with 0,2.5,5,10,20,40,80,and 160 μmol/L theaflavin,and the appropriate concentra-tion of action was screened.A549 cells were separated into control grou…查看全部>>
段兴隆;张华
陕西省汉中市人民医院呼吸内科,陕西 汉中 723000陕西省汉中市人民医院呼吸内科,陕西 汉中 723000
茶黄素磷脂酰肌醇3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白信号通路自噬肺癌
TheaflavinPhosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapa-mycin signaling pathwayAutophagyLung cancer
《河北医学》 2024 (9)
1473-1478,6
陕西省汉中市人民医院项目计划,(编号:sy-2023-02)
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