解放军医学杂志2024，Vol.49Issue(9)：1062-1072,11.DOI:10.11855/j.issn.0577-7402.0217.2023.0719
内质网自噬及其相关疾病研究进展
Research advances in endoplasmic reticulum autophagy and its roles in associated diseases
摘要
Abstract
Endoplasmic reticulum is an important organelle in eukaryotic cells,which is responsible for the folding,processing and transportation of secretory proteins.A variety of stimuli inside and outside cells can lead to the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum,resulting in abnormal structure and function of the endoplasmic reticulum,which is called endoplasmic reticulum stress(ERS).Endoplasmic reticulum autophagy is an important endogenous mechanism to alleviate ERS.It is often considered as a cell protective procedure,which participates in many important physiological processes,such as metabolism,immune response,inflammatory response and cell proliferation.Endoplasmic reticulum autophagy is an important endogenous protective mechanism to alleviate endoplasmic reticulum stress and restore the endoplasmic reticulum homeostasis,through eliminating redundant and disabled endoplasmic reticulum membrane and macromolecular protein complexes,which is critical to cell function and fate.This paper reviews the types of endoplasmic reticulum autophagy,related specific receptors,main regulatory mechanisms,and its role and significance in the related diseases.关键词
内质网应激/自噬/研究进展Key words
endoplasmic reticulum stress/autophagy/reasearch progress分类
医药卫生引用本文复制引用
童森,董宁,祝筱梅,姚咏明..内质网自噬及其相关疾病研究进展[J].解放军医学杂志,2024,49(9):1062-1072,11.基金项目
This work was supported by the National Natural Science Foundation of China(82130062,82241062,82272200) 国家自然科学基金(82130062,82241062,82272200) （82130062,82241062,82272200）
