高压氧联合静脉溶栓治疗大动脉粥样硬化型卒中及非大动脉粥样硬化型卒中患者的效果及短期转归影响因素分析OACSTPCD
The effect of hyperbaric oxygen combined with intravenous thrombolysis on large atherosclerotic stroke and non-large-atherosclerotic-stroke patients and the influencing factors of short-term outcome
目的 探讨高压氧联合静脉溶栓治疗大动脉粥样硬化型卒中(LAA)及非LAA的效果及影响其短期转归相关因素.方法 回顾性选择2020年10月至2022年10月于我院接受高压氧联合静脉溶栓治疗的前循环急性缺血性卒中患者104例,根据TOAST分型分为LAA组与非LAA组.比较两组临床结局及NIHSS评分变化,并评价治疗安全性.Logistic回归分析不同病因分型患者治疗后短期转归的相关影响因素.结果 本研究中,LAA组患者62例,非LAA组患者42例.两组间基线资料、临床结局、NIHSS评分及安全性结局的差异无统计学意义(均P＞0.05).Logistic回归分析表明,不同病因分型患者行高压氧联合静脉溶栓治疗后短期转归与TOAST分型无关(P＞0.05),而与高血压、高血脂症、基线NIHSS评分及白细胞计数/平均血小板体积(WMR)、红细胞分布宽度(RDW)有关(均P＜0.05).结论 高压氧联合静脉溶栓治疗LAA及非LAA的效果与安全性相当,治疗后其短期转归与高血压、高血脂症、基线NIHSS评分及WMR、RDW水平有关.
Objective To investigate the effects of hyperbaric oxygen combined with intravenous thrombolysis in the treatment of large atherosclerotic stroke(LAA)and non-LAA and the related factors affecting its short-term outcome.Methods One hundred and four patients with acute ischemic stroke of anterior circulation who received hyperbaric oxygen combined with intravenous thrombolysis in our hospital from October 2020 to October 2022 were retrospectively selected.According to TOAST classification,they were divided into LAA group and non-LAA group.The clinical outcome and NIHSS score were compared between the two groups,and the safety of treatment was evaluated.Logistic regression was used to analyze the related factors of short-term outcomes in patients with different etiological types after treatment.Results There were 62 patients in LAA group and 42 patients in non-LAA group.There was no significant difference between the two groups in the baseline data,clinical outcomes,NIHSS scores and safety outcomes(all P＞0.05).Logistic analysis showed that the short-term outcome of patients treated with hyperbaric oxygen combined with intravenous thrombolysis was not related to TOAST classification(P＞0.05),but was related to hypertension,hyperlipidemia,baseline NIHSS score,white blood cell count/mean platelet volume(WMR)and red blood cell distribution width(RDW)(all P＜0.05).Conclusion The efficacy and safety of hyperbaric oxygen combined with intravenous thrombolysis in LAA and non-LAA are comparable,and the short-term outcome after treatment is related to hypertension,hyperlipidemia,baseline NIHSS score,WMR and RDW levels.
洪春永;林庆金;江华;李清金;王梓豪;林达生;杨雅玲
363000 漳州,中国人民解放军联勤保障部队第九○九医院神经内科
临床医学
大动脉粥样硬化型卒中高压氧红细胞分布宽度白细胞计数/平均血小板体积
large atherosclerotic strokehyperbaric oxygenerythrocyte distribution widthwhite blood cell count/mean platelet volume
《临床神经病学杂志》 2024 (005)
345-349 / 5
福建省自然科学基金项目(2019J01144)
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