军事医学2024，Vol.48Issue(9)：708-714,7.DOI:10.7644/j.issn.1674-9960.2024.09.012
运载紫杉醇的干细胞递送系统研究进展
Research progress in delivery systems of mesenchymal stem cells carrying paclitaxel
摘要
Abstract
Mesenchymal stem cells have emerged as a promising cell therapy for anti-tumor research due to their homing properties,low immunogenicity,anti-angiogenic activity,anti-inflammatory properties,and paracrine effects.Paclitaxel has been clinically used for over thirty years in the treatment of various tumors such as ovarian cancer,lung cancer,and breast cancer.However,the broad-spectrum anti-tumor properties of paclitaxel are not possessed by the aforementioned cell therapies.Moreover,its adverse reactions,including peripheral neuropathy,bone marrow suppression,and gastrointestinal reactions,have long plagued cancer patients.In recent years,many studies have focused on combining cell therapy with chemotherapy to achieve better treatment outcomes,giving rise to a new drug delivery system that utilizes mesenchymal stem cells as carriers for delivering chemotherapeutic drugs.This review summarizes the research progress in MSC-based drug delivery systems for paclitaxel.关键词
间充质干细胞/药物递送系统/紫杉醇/肿瘤靶向治疗/肿瘤生物治疗/化学疗法/细胞疗法Key words
mesenchymal stem cells/drug delivery systems/paclitaxel/targeted cancer therapy/cancer biotherapy/chemotherapy/cell therapy分类
医药卫生引用本文复制引用
裴奕浩,陈思遥,宿玉音,茅怡铭,李笨..运载紫杉醇的干细胞递送系统研究进展[J].军事医学,2024,48(9):708-714,7.基金项目
国家级大学生创新创业训练项目(202313213001X) （202313213001X）
辽宁省教育厅基本科研面上项目(JYTMS20230682) （JYTMS20230682）
