临床肝胆病杂志2024，Vol.40Issue(10)：2087-2091,5.DOI:10.12449/JCH241026
CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用
The role of CD8+T cells in nonalcoholic steatohepatitis
摘要
Abstract
Nonalcoholic steatohepatitis(NASH)is a liver disease closely associated with metabolic syndrome,and its pathogenesis includes insulin resistance,lipid metabolism disorders,and inflammatory response.This article briefly describes how CD8+T cells exert a cytotoxic effect through the three pathways of the Fas-Fas ligand signaling pathway,the release of perforin and granzymes,and the secretion of tumor necrosis factor-α and other cytokines,and these mechanisms allow CD8+T cells to specifically kill virus-infected cells and tumor target cells,thereby participating in immune regulation.At the same time,this article summarizes that CD8+T cells promote the recruitment of macrophages cooperate with natural killer T cells to participate in the development of adipose tissue inflammation,and lead to liver injury through automatic attack and epigenetic mechanisms,finally promoting the pathogenesis of NASH.It is concluded that CD8+T cells may become a new therapeutic target for NASH,and in-depth research on the specific mechanism of CD8+T cells affecting the pathogenesis in NASH in the future may help to further guide clinical treatment.关键词
非酒精性脂肪性肝病/CD8阳性T淋巴细胞/脂肪组织/炎症/表观基因组学Key words
Non-alcoholic Fatty Liver Disease/CD8-Positive T-Lymphocytes/Adipose Tissue/Inflammation/Epigenetics引用本文复制引用
赵一鸣,李开楊,杨梅,赵琦..CD8+T淋巴细胞在非酒精性脂肪性肝炎中的作用[J].临床肝胆病杂志,2024,40(10):2087-2091,5.基金项目
国家自然科学基金项目(82160866) （82160866）
贵州省科技计划项目(黔科合基础-ZK[2023]一般433) （黔科合基础-ZK[2023]一般433）
贵州省卫生健康委科学技术基金资助项目(gzwkj2023-208) （gzwkj2023-208）
贵州省高等学校重点实验室(黔教技[2023]017号) National Natural Science Foundation of China(82160866) （黔教技[2023]017号）
Science and Technology Plan Project of Guizhou Province(Guizhou Science and Technology base-ZK[2023]General 433) （Guizhou Science and Technology base-ZK[2023]General 433）
Science and Technology Fund of Guizhou Provincial Health Commission(gzwkj2023-208) （gzwkj2023-208）
Key Laboratory of Higher Education in Guizhou Province(Guizhou Education Technology[2023]017) （Guizhou Education Technology[2023]017）
