临床肝胆病杂志2024，Vol.40Issue(10)：2092-2097,6.DOI:10.12449/JCH241027
NLRP3炎症小体在自身免疫性肝炎中的作用机制
Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis
摘要
Abstract
Autoimmune hepatitis(AIH)is chronic hepatitis caused by the attack of live cells by the immune system,and at present,the pathogenesis of AIH remains unclear.Inflammasomes are important components of innate immunity and are involved in a variety of pathophysiological processes.Studies have shown that inflammatory response associated with nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)plays an important role in the pathogenesis of AIH,which mainly mediates the release of proinflammatory factors and pyroptosis,thereby participating in the pathophysiological process of AIH.Therefore,the development and progression of AIH can be delayed by inhibiting the activation of NLRP3 inflammasomes,which provides new ideas for the prevention and treatment of AIH.关键词
肝炎,自身免疫性/NLR家族,热蛋白结构域包含蛋白3/治疗学Key words
Hepatitis,Autoimmune/NLR Family,Pyrin Domain-Containing 3 Protein/Therapeutics引用本文复制引用
王丽菲,罗龙龙,邢国静,卢利霞,李斌,张久聪,于晓辉..NLRP3炎症小体在自身免疫性肝炎中的作用机制[J].临床肝胆病杂志,2024,40(10):2092-2097,6.基金项目
甘肃省科技计划项目任务书(22YF7FA105) （22YF7FA105）
甘肃省卫生健康行业科研计划项目合同书(GSWSKY2021-054) （GSWSKY2021-054）
甘肃省非感染性肝病临床医学研究中心(21JR7RA017) （21JR7RA017）
联勤保障部队第九四〇医院基金临床医学肝病诊治中心(2021yxky079) Gansu Province Science and Technology Plan Project Assignment(22YF7FA105) （2021yxky079）
Gansu Province Health Industry Scientific Research Plan Project Contract(GSWSKY2021-054) （GSWSKY2021-054）
Gansu Clinical Medical Research Center for Non-infectious Liver Diseases(21JR7RA017) （21JR7RA017）
Liver Disease Diagnosis and Treatment Center,940th Hospital Foundation,Joint Logistics Support Force(2021yxky079) （2021yxky079）
