临床肝胆病杂志2024，Vol.40Issue(10)：2104-2108,5.DOI:10.12449/JCH241029
他汀类药物在慢性肝病中的作用
Role of statins in chronic liver disease
摘要
Abstract
Chronic liver disease is the"devil's trilogy"in which the liver progresses from inflammation and fibrosis to liver cirrhosis and hepatocellular carcinoma,which poses a great challenge for hepatologists worldwide.Statins have played a significant role in the treatment of cardiovascular diseases and hyperlipidemia since their introduction,and in recent years,they have also demonstrated the potential to improve hepatic steatosis,exert an anti-inflammatory effect,regulate the phenotype of hepatic stellate cells,reduce portal venous pressure,and improve hepatic microcirculation in chronic liver disease.This article reviews the latest advances in the basic and clinical studies of statins in chronic liver disease,in order to provide new insights into the research,prevention,and treatment of chronic liver disease.关键词
羟甲基戊二酰基CoA还原酶抑制剂/肝纤维化/肝硬化/癌,肝细胞Key words
Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hepatic Fibrosis/Liver Cirrhosis/Carcinoma,Hepatocellular引用本文复制引用
杨希坤,李晖,曾子键,吴旋,王凯鑫..他汀类药物在慢性肝病中的作用[J].临床肝胆病杂志,2024,40(10):2104-2108,5.基金项目
国家自然科学基金面上项目(82274323) General Project of National Natural Science Foundation of China(82274323) （82274323）
