解放军医学杂志2024，Vol.49Issue(9)：1094-1098,5.DOI:10.11855/j.issn.0577-7402.1579.2024.0418
IRAK4在血液系统恶性肿瘤中的作用及其机制研究进展
Research progress on the role and mechanism of IRAK4 in hematological malignancies
摘要
Abstract
Interleukin-1 receptor associated kinase 4(IRAK4)plays a crucial role in signal transduction and regulation in the TLRs/IL-1R signaling pathway,coordinating multiple inflammatory pathways involving immune system activation,cytokine production,and cell proliferation and differentiation.IRAK4 is associated with the pathogenesis and progression of hematological malignancies,including myelodysplastic syndrome,acute myeloid leukemia,chronic lymphocytic leukemia,and lymphoma.Therefore,IRAK4 may serve as an effective therapeutic target for hematologic malignancies.This review summarizes the research advances in the structure and function of IRAK4,as well as its mechanism of action and therapeutic implications in hematological malignancies,aiming to provide insights into pathogenesis of related diseases and targeted therapy research.关键词
白细胞介素-1受体相关激酶4/血液系统恶性肿瘤/发病机制/靶向治疗Key words
Interleukin-1 receptor associated kinase 4/hematological malignancies/pathogenesis/targeted therapy分类
临床医学引用本文复制引用
商颖,李莉娟,张连生..IRAK4在血液系统恶性肿瘤中的作用及其机制研究进展[J].解放军医学杂志,2024,49(9):1094-1098,5.基金项目
This work was supported by the National Natural Science Foundation of China(82360029) 国家自然科学基金(82360029) （82360029）
