环境与职业医学2024，Vol.41Issue(9)：1075-1081,7.DOI:10.11836/JEOM24098
食源性纳米材料与结直肠癌发病风险的探讨
Potential risk of colorectal cancer associated with foodborne nanomaterials
摘要
Abstract
Colorectal cancer is a globally prevalent malignant tumor,and its incidence continues to rise along with the popularity of Westernized dietary habits.With the rapid development of nan-otechnology,nanomaterials are widely applied in the food sector,inevitably leading to direct or indirect ingestion of nanoparticles through daily dietary intake.Numerous studies have indicated that oral exposure to nanomaterials may trigger or exacerbate gastrointestinal diseases such as inflammatory bowel disease,and even hinder their recovery,which is considered as a crucial step in the occurrence and development of colorectal cancer.Longer duration of colitis may ele-vate the risk of developing colorectal cancer;more extensive colonic surface affected by colitis may elevate the risk of developing colorectal cancer too.In order to further understand the bio-logical effects of foodborne nanomaterials on the occurrence and development of colorectal cancer,this paper reviewed common applications of nanomaterials in food and food industry,in-troduced common pathogenic mechanisms of colorectal cancer,and explored the potential impact of foodborne nanomaterials on the occurrence and development of colorectal cancer based on their roles in inducing chronic intestinal inflammation and dysbiosis.Furthermore,it discussed future epidemiological and toxicological research prospects,aiming to provide reference for a comprehensive evaluation of the safety of nanomaterials in food and guidance of healthy diet for colorectal cancer patients.关键词
食品/纳米材料/肠道菌群/炎症/炎症性肠病/结直肠癌Key words
food/nanomaterial/gut microbiota/inflammation/inflammatory bowel disease/col-orectal cancer分类
医药卫生引用本文复制引用
何郎志,王云..食源性纳米材料与结直肠癌发病风险的探讨[J].环境与职业医学,2024,41(9):1075-1081,7.基金项目
国家自然科学基金项目(31971313) （31971313）
国家重点研发计划项目(2022YFA1205703) This study was funded. （2022YFA1205703）
