青岛大学学报（医学版）2024，Vol.60Issue(4)：483-486,4.DOI:10.11712/jms.2096-5532.2024.60.080
不同时间ARS对雄性CD1小鼠运动及情绪影响
Influence of different durations of acute restraint stress on the motor ability and emotion of male CD1 mice
摘要
Abstract
Objective To investigate the influence of different durations of acute restraint stress(ARS)on motor ability,anxiety,and depression-like behavior in male CD1 mice.Methods Male CD1 mice aged 8 weeks were randomly divided into con-trol group,0.5 h ARS group,1.0 h ARS group,2.0 h ARS group,and 4.0 h ARS group,with 10 mice in each group,and the su-crose preference test,the open field test,and the elevated plus maze test were performed after modeling.Results The sucrose preference test showed that there was no significant difference in the percentage of sucrose preference between the ARS groups and the control group.The open field test showed that there were no significant differences in total movement distance and movement speed between the ARS groups and the control group.The elevated plus maze testshowed that compared with the control group,the 0.5 h ARS group,the 1.0 h ARS group,and the 2.0 h ARS group had significant reductions in the number of times of entering the open arm(q=4.483-6.150,P＜0.01)and the time spent in the open arm(q=3.607-4.665,P＜0.05),while there were no significant differences in these two indicators between the 4.0 h ARS group and the control group.Conclusion Different dura-tions of ARS do not affect the depression-like behavior and motor ability of CD1 mice,but ARS for 0.5,1.0,and 2.0 h can induce anxiety-like behavior in CD1 mice.关键词
急性束缚应激/心理困扰/焦虑/移动/抑郁/小鼠,近交ICRKey words
acute restraint stress/psychological distress/anxiety/locomotion/depression/mice,inbred ICR分类
医药卫生引用本文复制引用
王潇娅,潘雪凝,徐许峰,谢俊霞,徐华敏..不同时间ARS对雄性CD1小鼠运动及情绪影响[J].青岛大学学报（医学版）,2024,60(4):483-486,4.基金项目
国家自然科学基金面上项目(32371187) （32371187）
