青岛大学学报（医学版）2024，Vol.60Issue(4)：574-577,4.DOI:10.11712/jms.2096-5532.2024.60.117
大骨瓣渐进与常规减压术救治重症颅脑损伤效果评价
Efficacy of large bone flap progressive decompression versus conventional decompression in treatment of severe craniocerebral injury
摘要
Abstract
Objective To investigate the efficacy of large bone flap progressive decompression in the treatment of severe craniocerebral injury and its effect on neurocytokines and inflammatory factors.Methods A total of 120 patients with severe craniocerebral injury who were treated in Nantong Third People's Hospital from January 2019 to December 2022 were enrolled as subjects,and they were randomly divided into study group and control group,with 60 patients in each group.The patients in the study group received progressive decompression,and those in the control group received conventional decompression.The two groups were compared in terms of treatment outcome,NIH Stroke Scale score,Glasgow Coma Scale(GCS)score,and neurologi-cal function.Results Compared with the control group,the study group had significantly lower midline displacement and in-tracranial pressure at different time points(t=27.706,F=12.135-29.915,P＜0.001),as well as a significantly lower NIHSS score and a significantly higher GCS score(t=3.388-7.844,P＜0.001).After surgery,compared with the control group,the stu-dy group had significantly higher levels of stress response factors such as serum renin,epinephrine,angiotensin Ⅱ,and norepi-nephrine(t=4.147-70.340,P＜0.001)and significantly lower levels of related inflammatory,circulatory,and neurological fac-tors(t=5.127-9.763,P＜0.001).After surgery,the study group had significantly higher total score and scores of cognitive func-tion,physical function,social function,and emotional function than the control group(t=8.226-31.690,P＜0.001).Conclu-sion Large bone flap progressive decompression has a better clinical effect in the treatment of patients with severe craniocerebral injury,with significant recovery of inflammatory and stress response and circulatory and neurological functions and better quality of life.关键词
颅脑损伤/颅内出血,创伤性/颅内高压/颅骨切开术/治疗结果Key words
craniocerebral trauma/intracranial hemorrhage,traumatic/intracranial hypertension/craniotomy/treatment outcome分类
医药卫生引用本文复制引用
陈强,刘锦平,钱忠伟..大骨瓣渐进与常规减压术救治重症颅脑损伤效果评价[J].青岛大学学报（医学版）,2024,60(4):574-577,4.基金项目
江苏省卫生健康委员会医学科研项目(GY202203) （GY202203）
