青岛大学学报（医学版）2024，Vol.60Issue(4)：607-610,4.DOI:10.11712/jms.2096-5532.2024.60.118
局部晚期宫颈癌淋巴结转移的危险因素及预后分析
Risk factors for lymph node metastasis in locally advanced cervical cancer and their impact on prognosis
摘要
Abstract
Objective To investigate the high-risk factors for lymph node metastasis in locally advanced cervical cancer(LACC)and their impact on prognosis.Methods A retrospective analysis was performed for the clinical data of 97 patients with stage I B2-ⅣA LACC,among whom 55 patients experienced lymph node metastasis.A Logistic regression analysis was used to investigate the high-risk factors for lymph node metastasis,and the Kaplan-Meier curve and the Log-rank test were used to investi-gate the impact of lymph node metastasis and its high-risk factors on progression-free survival(PFS).Results The univariate a-nalysis showed that there were significant differences between the positive lymph node metastasis group and the negative group in age,International Federation of Gynecology and Obstetrics(FIGO)stage,squamous cell carcinoma antigen(SCCA),carbohy-drate antigen 125,white blood cell count,hemoglobin,neutrophil count,tumor size,and depth of stromal invasion(t=-3.157 to 2.173,U=12.314-1 569.000,P＜0.05).The multivariate analysis showed that FIGO stage(OR=3.204,95％CI=2.423-6.153,P=0.004),SCCA level(OR=1.050,95％CI=1.009-1.092,P=0.017),and tumor size(OR=1.045,95％CI=1.015-1.076,P=0.003)were independent risk factors for lymph node metastasis.The survival analysis showed that lymph node metastasis(HR=3.944,95％CI=1.744-8.920,P=0.001)was an influencing factor for PFS,and in addition,FIGO stage(HR=2.749,95％CI=1.216-6.215,P=0.015),SCCA level(HR=20.552,95％CI=6.419-65.796,P＜0.001),and tumor size(HR=9.384,95％CI=2.614-33.687,P＜0.001)had a good risk stratification value for PFS in LACC.Conclusion FIGO stage,SCCA level,and tumor size are independent risk factors for lymph node metastasis in LACC.关键词
宫颈肿瘤/淋巴转移/预后/危险因素Key words
uterine cervical neoplasms/lymphatic metastasis/prognosis/risk factors分类
医药卫生引用本文复制引用
曲晓丽,张娜,李发红..局部晚期宫颈癌淋巴结转移的危险因素及预后分析[J].青岛大学学报（医学版）,2024,60(4):607-610,4.基金项目
中国博士后科学基金资助项目(2019M662307) （2019M662307）
