食管疾病2024，Vol.6Issue(3)：184-188,5.DOI:10.15926/j.cnki.issn2096-7381.2024.03.004
放射治疗对食管鳞癌患者口腔牙龈卟啉单胞菌的清除作用
The Impact of Radiation Therapy on Oral Porphyromonas gingivalis in Patients with Esophageal Cancer
摘要
Abstract
Objective To detect the changes of oral Pg before,during and after radiotherapy in patients with esophageal cancer,and to explore the role of radiotherapy on oral Pg clearance.Methods Thirty pa-tients with pathologically proven esophageal squamous cell carcinoma were selected for the formulation of a modulated intensity modulated radiotherapy plan using the Elekta-precise planning system.The prescribed dose was 50～50.4 Gy/25～28 times.Oral swabs(6 per person,180 in total)were collected once a week be-fore,during and after radiotherapy.Quantitative detection of Pg was performed by qPCR.Statistical data were analyzed by rank sum test.Results The results of initial oral Pg detection in 30 patients with esophageal cancer were as follows:60％(18/30)were negative and 40％(12/30)were positive.Among the 12 positive patients,83.33％(10/12)were negative and 16.67％(2/12)were still positive after radiotherapy(for the two patients,the amount of Pg was significantly reduced compared with that before radiotherapy(P＜0.05).Conclusion Patients with esophageal cancer,oral Pg can be simultaneously eliminated or reduced dur-ing radiotherapy on the cancer.关键词
食管鳞癌/适形调强放疗/牙龈卟啉单胞菌Key words
esophageal squamous cell carcinoma/intensity modulated radiotherapy/Porphyromonas gingi-valis分类
医药卫生引用本文复制引用
倪蕾,高社干,贾瑞诺,谷变利,张军千,王子琪,李柳燕,刘晓艺,杨丹妮,陈攀,李宝生..放射治疗对食管鳞癌患者口腔牙龈卟啉单胞菌的清除作用[J].食管疾病,2024,6(3):184-188,5.基金项目
河南省重点研发与推广项目(242102310432)洛阳市科技发展计划(2302015Y) （242102310432）
