食管疾病2024，Vol.6Issue(3)：189-195,236,8.DOI:10.15926/j.cnki.issn2096-7381.2024.03.005
牙龈卟啉单胞菌:从毒力因子到疫苗研发
Porphyromonas Gingivalis:From Virulence Factor to Vaccine Development
摘要
Abstract
Porphyromonas gingivalis(Pg)has been proved to be one of gram-negative oral pathogens,which colonizes in the gingival anaerobe biofilm and causes local periodontitis.Pg spreads from colonized gums to other body parts through body fluids to cause a variety of systemic diseases,such as cardiovascular and ce-rebrovascular diseases,autoimmune diseases,Alzheimer's disease,cancer.It is difficult for the drug to reach the gum and continuous administration of the drug is easy to cause drug resistance of the bacteria,and the e-radication effect cannot be achieved.Therefore,the selection of appropriate antigen sites to stimulate the im-mune system to produce neutralizing antibodies is the key to vaccine research.In this paper,the pathogenesis and mechanism of Pg were summarized,and the related virulence factors were comprehensively reviewed to provide targets for the elimination and prevention of Pg infection,and the potential of these virulence factors as vaccines was evaluated and analyzed from the per-spective of vaccinology.关键词
牙龈卟啉单胞菌/毒力因子/疫苗/免疫原Key words
Porphyromonas gingivalis/virulence factor/vaccine/immunogen分类
医药卫生引用本文复制引用
李伟,李智涛,王烁,高社干..牙龈卟啉单胞菌:从毒力因子到疫苗研发[J].食管疾病,2024,6(3):189-195,236,8.基金项目
1.国家自然科学基金(81972571)2.许昌市重点研发与推广专项(科技攻关、软科学研究)备案项目(20230213093) （81972571）
