食管疾病2024，Vol.6Issue(3)：212-216,5.DOI:10.15926/j.cnki.issn2096-7381.2024.03.009
内镜联合药物治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效及再出血危险因素分析
Analysis of Clinical Efficacy and Risk Factors of Rebleeding of Esophageal and Gastric Varices Treated with Endoscopy Combined with Drugs in Cirrhotic Patients
滕飞 1陈志强 2严亚辉1
作者信息
- 1. 信阳市人民医院,河南信阳,464000
- 2. 信阳市中心医院,河南信阳,464000
- 折叠
摘要
Abstract
Objective To study the efficacy and risk factors for rebleeding during the treatment of esoph-ageal variceal bleeding(EGVB)in patients with liver cirrhosis using an endoscopic combined medication regimen.Methods 200 liver cirrhosis patients with EGVB treated in our hospital from January 30,2021 to January 30,2023 were selected and divided into observation group and control group with 100 cases each randomly.The control group was treated with simple drug therapy,and the observation group was treated with endoscopic combined drug therapy.The clinical efficacy of the two groups was compared,and the risk factors of rebleeding in liver cirrhosis patients with EGVB were determined by univariate and multivariate Logistic re-gression analysis.Results The total effective rate of observation group was higher than that of control group(92.00％VS 71.00％)(P＜0.05).The proportion of patients treated with endoscope combined with drugs in the rebleeding group was lower than that in the non-rebleeding group(31.25％VS 73.86％)(P＜0.05).There was no significant difference in other baseline data between the two groups(all P＞0.05).The levels of albumin and sodium in rebleeding group were(24.31±3.87)g·L-1 and(126.02±10.71)mmol·L-1,respectively,which were lower than those in no re-bleeding group(31.50±4.56)g·L-1 and(138.02±12.45)mmol·L-1(all P＜0.05).Multi-variate Logistic regression analysis confirmed that the risk factors for rebleeding in EGVB patients with cir-rhosis included simple drug treatment,decreased albumin and decreased blood sodium(OR=1.862,2.425,2.661,P＜0.001).Conclusion The clinical efficacy of endoscopic combined drug therapy for EGVB in liver cirrhosis is better,while patients with simple drug therapy and low albumin and sodium levels have a higher risk of rebleeding.关键词
肝硬化/食管胃底静脉曲张/破裂出血/内镜/再出血/危险因素Key words
cirrhosis/esophageal and gastric varices/rupture bleeding/endoscope/rebleeding/risk factor分类
医药卫生引用本文复制引用
滕飞,陈志强,严亚辉..内镜联合药物治疗肝硬化食管胃底静脉曲张破裂出血的临床疗效及再出血危险因素分析[J].食管疾病,2024,6(3):212-216,5.
