药学研究2024，Vol.43Issue(9)：880-886,7.DOI:10.13506/j.cnki.jpr.2024.09.009
虚弱症啮齿类动物模型研究进展
Advances in the rodent models of frailty
摘要
Abstract
Frailty is an age-related clinical syndrome characterized by a decline in multi-system physiological functions and increased susceptibility to stressors.The underlying molecular mechanisms of frailty remain incompletely un-derstood.Rodent frailty models can be classified into ① gene-edited developed on basis of disease-related pathology,and②non-gene-edited models that include frailty phenotype or frailty index assessment models and inducible models.This re-view summarized the research progress in rodent frailty models,and analyzes their advantages and disadvantages,and pre-liminary discussion of future development,hoping to provide a reference for frailty-related research.关键词
虚弱症/啮齿类动物/动物模型/虚弱表型/虚弱指数Key words
Frailty/Rodent animals/Animal model/Frailty phenotype/Frailty index分类
药学引用本文复制引用
韦彩绿,沈千惠,郭海燕,徐俊,皮荣标..虚弱症啮齿类动物模型研究进展[J].药学研究,2024,43(9):880-886,7.基金项目
国家自然科学基金项目(No.81671264) （No.81671264）
科技部科技创新2030(No.SQ2023AAA031458) （No.SQ2023AAA031458）
科技部重点研发项目(No.2021YFC2500103) （No.2021YFC2500103）
国家自然科学基金面上项目(No.82471212、82071187) （No.82471212、82071187）
