内蒙古民族大学学报（自然科学版）2024，Vol.39Issue(5)：52-60,9.DOI:10.14045/j.cnki.15-1220.2024.05.010
基于网络药理学及分子对接技术研究菝葜治疗银屑病的作用机制
Studying the Action Mechanism of BaQia in Treating Psoriasis Based on Network Pharmacology and Molecular Docking Technology
摘要
Abstract
The action mechanism of BaQia in the treatment of psoriasis vulgaris was explored in depth by us-ing the research method of network pharmacology.The active ingredients of BaQia and their targets were screened using the traditional Chinese medicine(TCM)systemic pharmacology database,and intersected with the targets of psoriasis vulgaris,thus obtained the potential targets of BaQia for treatment of psoriasis vulgaris.A protein PPI net-work was constructed for these targets,and further GO function analysis and KEGG pathway enrichment analysis were performed.The analysis results showed that BaQia contained 13 active components,which interacted with 76 target proteins and collectively participated in 25 key pathways closely related to psoriasis vulgaris.These biological functions covered a wide range of biological processes,including regulation of lipid metabolic processes,macromolec-ular complexes,enzyme binding,etc.The main enriched pathways for BaQia treatment of psoriasis were IL-17 sig-nalling pathway and TNF signalling pathway.Molecular docking experiments further confirmed that the core compo-nents of BaQia could effectively bind to these core targets to exert therapeutic effects.The study preliminarily re-vealed that the efficacy of BaQia as an effective traditional Chinese medicine in the treatment of psoriasis vulgaris might be related to the modulation of key targets such as IL-17 and TNF signalling pathways.This result provided a more in-depth theoretical basis for the application of BaQia in the treatment of psoriasis.关键词
菝葜/银屑病/网络药理/分子对接Key words
BaiQia/psoriasis/network pharmacology/molecular docking分类
医药卫生引用本文复制引用
田雨,王乌云塔娜..基于网络药理学及分子对接技术研究菝葜治疗银屑病的作用机制[J].内蒙古民族大学学报（自然科学版）,2024,39(5):52-60,9.基金项目
内蒙古自治区自然科学基金项目(2019LH08034) （2019LH08034）
内蒙古民族大学附属医院博士启动基金项目(2020BS02) （2020BS02）
