基于UHPLC/Q-Orbitrap-MS的石决明散化学成分鉴定及降压作用网络药理学研究OACSTPCD
Identification of chemical compounds of Shi-Jue-Ming-San based on ultra-high performance liquid chromatography-quadrupole Orbitrap mass spectrometry and its network pharmacology in treatment of hypertension
[目的]基于入血成分分析和网络药理学探讨石决明散(SJMS)抗高血压(HT)的潜在作用机制.[方法]利用超高效液相色谱-四级杆/静电场轨道阱高分辨质谱联用(UHPLC/Q-Orbitrap-MS)技术对SJMS中的主要化学成分和入血成分进行定性分析,利用SEA和SwissTargetPrediction数据库预测入血成分的作用靶点;借助GeneCards和DrugBank数据库获得HT的相关靶点;通过String平台和Cytoscape软件对SJ…查看全部>>
[Objective]Based on the analysis of absorbed components in blood and network pharmacology,the potential mechanism of Shi-Jue-Ming-San(SJMS)in treating hypertension(HT)was explored.[Methods]Qualitative analysis was conducted on the main chemical compounds in vivo and in vitro of SJMS using the ultra-high performance liquid chromatography-quadrupole Orbitrap mass spectrometry(UHPLC/Q-Orbitrap-MS),and the targeted protein of active compounds were predicted usin…查看全部>>
米未;王影;付志飞
天津市胸科医院,天津 300350天津中医药大学,天津 301617天津中医药大学,天津 301617
中医学
石决明散化学成分高血压网络药理学作用机制
Shi-Jue-Ming-Sanchemical compositionhypertensionnetwork pharmacologymechanism of action
《天津中医药大学学报》 2024 (9)
787-797,11
天津市卫生健康委员会中医中西医结合科研课题项目(2021161).
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