特产研究2024，Vol.46Issue(5)：42-47,6.DOI:10.16720/j.cnki.tcyj.2024.158
避瘟解毒颗粒对LPS诱导急性肺损伤小鼠保护作用的研究
Protective Effect of BiWen Jiedu Granules on LPS-induced Acute Lung Injury in Mice
摘要
Abstract
To explore the effect BiWen Jiedu Granules on LPS-induced acute lung injury in mice.Thirty male C57 mice were randomly di-vided into the normal group,the model group,the dexamethasone group,and the low-dose and high-dose groups of BiWen Jiedu Granules,with 6 in each group,which were administered once a day for 7 days.The acute lung injury model was established by tracheal infusion of lipopolysaccharide(LPS)in the model group,the dexamethasone group,and the low-dose and high-dose groups of BiWen Jiedu Granules group.The material was taken at 72 h,the rats had their body weights,blood routine detected,their bronchoalveolar lavage fluid(BALF)lev-els of IL-1β,IL-6 and TNF-α detected by ELISA;the lung histopathological changes were observed by the HE staining.Compared with the modeld group,the the high-dose BiWen Jiedu Granules group shared lower degree of blood routine,levels of inflammatory cytokine IL-6 and TNF-αin BALF,lung injury(P＜0.05,P＜0.01),high-dose groups can increase the thymus index of ALI mice obviously(P＜0.01).BiWen Jiedu Granules plays a protective role in LPS-induced acute lung injury in mice,improve the histopathological changes of lung,enhance immune function and its mechanism may be related to inhibiting the secretion of inflammatory cytokines function.关键词
避瘟解毒颗粒/脂多糖/急性肺损伤/炎症因子Key words
BiWen Jiedu Granules/lipopolysaccharide/acute lung injury/inflammatory cytokine分类
医药卫生引用本文复制引用
王园,杨允,王博,崔妮,王海峰,张红,刘洋,龙凯花,卫向锋..避瘟解毒颗粒对LPS诱导急性肺损伤小鼠保护作用的研究[J].特产研究,2024,46(5):42-47,6.基金项目
陕西省重点研发计划项目(2022ZDXM-SF-06) （2022ZDXM-SF-06）
秦创原中医药创新研发转化项目(2022-QCYZH-006) （2022-QCYZH-006）
"秦药"研发重点实验室(2021-QYPT-001) （2021-QYPT-001）
"秦药"质量提升工程项目(2021-QYZL-01) （2021-QYZL-01）
陕西省科协青年人才托举计划项目(20230321) （20230321）
西安市科技计划项目(23YXYJ0142) （23YXYJ0142）
陕西省科技厅一般项目(2024SF-YBXM-489) （2024SF-YBXM-489）
