无机材料学报2024，Vol.39Issue(9)：1044-1052,中插1,10.DOI:10.15541/jim20240154
基于乙二胺四乙酸插层锌铝双金属氢氧化物的晚期肿瘤抗转移免疫治疗研究
Anti-metastatic Immunotherapy of Advanced Tumors Based on EDTA Intercalated Zinc-aluminum Layered Double Hydroxide
摘要
Abstract
Systemic metastasis of cancer cells is currently the main cause of death for patients with advanced cancer.Due to the rapid proliferation of tumor cells and abnormal deposition of extracellular matrix,the large-volume tumor tissue in advanced cancer is dense and stiff,which brings great difficulties to the treatment of advanced solid tumors:conventional drugs having difficulty in penetrating and immune cells facing challenges to infiltrate into their interior.Meanwhile,tumor cells on hard matrices have stronger invasive ability,which is prone to cause systemic metastasis of tumors.To solve this problem,this study prepared ethylenediaminetetraacetic acid(EDTA)intercalated zinc-aluminum layered double hydroxide nanomaterials(EDTA/LDH).Based on two parallel Ca2+deprivation mechanism,the anti-metastasis immunotherapy of EDTA/LDH material system for advanced large-volume solid tumors was studied.In the slightly acidic tumor microenvironment,the material system adheres to the tumor cell membrane through electrostatic force,releases EDTA to chelate Ca2+in cell adhesion proteins,cuts off part of the cell connections,reduces the stiffness of large tumors,and promotes the infiltration of immune cells into the tumor tissue.In addition,the material system is phagocytosed by macrophages as a"foreign body",causing calcium store-operated calcium influx,activating the anti-tumor immune effect of macrophages,and inhibiting the tumor-promoting invasion of polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)and regulatory T cells(Tregs).This study will provide reference ideas and methods for the anti-metastasis treatment of advanced malignant solid tumors.关键词
晚期癌症/免疫治疗/无机纳米材料/离子调控Key words
advanced cancer/immunotherapy/inorganic nanomaterial/ion regulation分类
医药卫生引用本文复制引用
李世奇,鲍群群,胡萍,施剑林..基于乙二胺四乙酸插层锌铝双金属氢氧化物的晚期肿瘤抗转移免疫治疗研究[J].无机材料学报,2024,39(9):1044-1052,中插1,10.基金项目
国家重点研发计划(2022YFB3804500) （2022YFB3804500）
国家自然科学基金(22322509,52072394,22335006) （22322509,52072394,22335006）
上海市优秀学科带头人计划(23XD1424200) （23XD1424200）
上海市科委基础研究项目(23DX1900200) （23DX1900200）
中国科学院前沿科学重点计划(ZDBS-LYSLH029) （ZDBS-LYSLH029）
上海市青年科技英才扬帆计划(22YF1433400)National Key R&D Program of China(2022YFB3804500) （22YF1433400）
National Natural Science Foundation of China(22322509,52072394,22335006) （22322509,52072394,22335006）
Program of Shanghai Academic/Technology Research Leader(23XD1424200) （23XD1424200）
The Basic-Research-Program of Shanghai Municipal Goverment(23DX1900200) （23DX1900200）
Key Research Program of Frontier Sciences,Chinese Academy of Sciences(ZDBS-LYSLH029) （ZDBS-LYSLH029）
Shanghai Yangfan Program(22YF1433400) （22YF1433400）
