1型糖尿病与卵巢癌之间的因果关系:一项孟德尔随机化研究OACSTPCD
Causal relationship between type 1 diabetes and ovarian cancer:a Mendelian randomization study
目的 探计1型糖尿病(type 1 diabetes,T1DM)和卵巢癌(ovarian cancer,OC)之间的双向因果关系.方法 采用两样本孟德尔随机化(MR)设计,使用来自全基因组关联研究(GWAS)的T1DM遗传变异(9 266例欧洲血统病例和15 574例对照)和OC遗传变异(1 218例欧洲血统病例和198 523例对照).采用MR-Egger、加权中位数(WME)、逆方差加权法(IVW)、简单模式(simple mode)和加权模…查看全部>>
Objective To assess the bidirectional causality between type 1 diabetes mellitus(T1DM)and ovarian cancer(OC).Methods Gene variants for T1DM(9 266 European ancestry patients and 15 574 controls)and OC(1 218 European ancestry patients and 198 523 controls)from genome-wide association studies(GWAS)were used in a two-sample Mendelian randomization(MR)design.MR-Egger,weighted median(WME),inverse variance weighting(IVW),simple mode and weighted mode were used to t…查看全部>>
张玲;吴媛霞;乔翠峰;杜秀萍
山西省妇幼保健院妇产科,太原 030012山西省妇幼保健院医学生殖中心山西省妇幼保健院妇产科,太原 030012山西省妇幼保健院妇产科,太原 030012
临床医学
1型糖尿病卵巢癌全基因组关联研究孟德尔随机化因果关系
type 1 diabetesovarian cancergenome-wide association studyMendelian randomizationcausal relationship
《山西医科大学学报》 2024 (9)
1122-1126,5
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