山西医科大学学报2024，Vol.55Issue(9)：1122-1126,5.DOI:10.13753/j.issn.1007-6611.2024.09.004
1型糖尿病与卵巢癌之间的因果关系:一项孟德尔随机化研究
Causal relationship between type 1 diabetes and ovarian cancer:a Mendelian randomization study
张玲 1吴媛霞 2乔翠峰 1杜秀萍1
作者信息
- 1. 山西省妇幼保健院妇产科,太原 030012
- 2. 山西省妇幼保健院医学生殖中心
- 折叠
摘要
Abstract
Objective To assess the bidirectional causality between type 1 diabetes mellitus(T1DM)and ovarian cancer(OC).Methods Gene variants for T1DM(9 266 European ancestry patients and 15 574 controls)and OC(1 218 European ancestry patients and 198 523 controls)from genome-wide association studies(GWAS)were used in a two-sample Mendelian randomization(MR)design.MR-Egger,weighted median(WME),inverse variance weighting(IVW),simple mode and weighted mode were used to test the causal relationship between T1DM and OC.Leave-one-out sensitivity analysis was used to assess the reliability of the results.Finally,MR Steiger test was used to test the hypothesized relationship between exposure and outcome.Results The results of IVW showed a causal relationship between T1DM and the incidence of OC(OR=1.000 4,95%CI 1.000 1-1.000 8,P=9.01×10-3),and the estimates of the above five methods were consistent in direction,indicating that T1DM was a risk factor for the incidence of OC.The MR Egger model confirmed that there was no significant heterogeneity in the results(P>0.05).There was no significant difference in the results when a single SNP was removed from the sensitivity analysis and the repeated MR analysis was carried out.The Egger intercept was close to zero(intercept<-0.001,P=0.191),indicating that there was no horizontal pleiotropy in this study.Meanwhile,reverse MR analysis did not show any evidence that OC increased the risk of T1DM(OR=0.988,95%CI 3.09×10-5-3.16×104,P=0.998).Conclu-sion Genetic evidence shows that T1DM can be associated with the OC risk increase,while OC can not increase the risk of T1DM.关键词
1型糖尿病/卵巢癌/全基因组关联研究/孟德尔随机化/因果关系Key words
type 1 diabetes/ovarian cancer/genome-wide association study/Mendelian randomization/causal relationship分类
医药卫生引用本文复制引用
张玲,吴媛霞,乔翠峰,杜秀萍..1型糖尿病与卵巢癌之间的因果关系:一项孟德尔随机化研究[J].山西医科大学学报,2024,55(9):1122-1126,5.
