间歇禁食通过调控FGF21分子改善压力超负荷型心力衰竭OACSTPCD
Intermittent fasting improves pressure overload-induced heart failure by regulating FGF21 molecule
目的 明确间歇禁食(intermittent fasting,IF)对压力超负荷型心衰的保护作用及潜在分子机制.方法 采用主动脉弓缩窄术(transverse aortic constriction,TAC)建立压力超负荷型心衰模型,术后给予自由进食(ad libitum,ALb)或IF处理.将C57BL/6小鼠随机分为假手术+自由进食组(sham+ALb)、假手术+间歇禁食组(sham+IF)、心衰+自由进食组(TAC+ALb)和心衰+间歇禁食…查看全部>>
Objective To investigate the protective effect of intermittent fasting(IF)against the pressure overload-induced heart failure and its potential molecular mechanism.Methods The model of pressure overload-induced heart failure was established by transverse aortic constriction(TAC),and the mice were treated with ad libitum(ALb)or IF after operation.C57BL/6 mice were randomly divided into sham+ALb group,sham+IF group,TAC+ALb group and TAC+IF group.Wild-type(WT)a…查看全部>>
安慧仙;孙梦娜;王瑞;曾广伟
西安国际医学中心医院心内科,西安 710100西安国际医学中心医院心内科,西安 710100西安国际医学中心医院心内科,西安 710100西安国际医学中心医院心内科,西安 710100
临床医学
间歇禁食压力超负荷心衰成纤维细胞生长因子21线粒体去乙酰化酶3
intermittent fastingpressure overloadheart failurefibroblast growth factor 21mitochondrialSIRT3
《山西医科大学学报》 2024 (9)
1133-1143,11
陕西省重点研发项目(2023-YBSF-576)
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